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Gene Review:

RCI2A - Hydrophobic protein RCI2A

Arabidopsis thaliana

Synonyms: F10A16.18, F10A16_18, RARE-COLD-INDUCIBLE 2A

Capel, J. et al., Medina, J. et al., Medina, J. et al., Mitsuya, S. et al., Nylander, M. et al.

Nylander, Heino, Helenius, Palva, Ronne, Welin,

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Disease relevance of RCI2A

To understand their developmental regulation and obtain possible clues on their functions, we have isolated genomic clones for RCI2A and RCI2B, two genes from Arabidopsis ecotype Columbia (Col), whose expression is induced in response to low temperature, dehydration, salt stress, and abscisic acid [1].

High impact information on RCI2A

These mutants also displayed deregulated RCI2A expression in response to ABA, DH or NaCl [2].
To uncover new pathways involved in low-temperature signal transduction, we screened for mutants altered in cold-induced expression of RCI2A, an Arabidopsis gene that is not a member of the CBF/DREB1 regulon and is induced not only by low temperature but also by abscisic acid (ABA), dehydration (DH) and NaCl [2].
This was accomplished by generating a line of Arabidopsis carrying a transgene consisting of the RCI2A promoter fused to the firefly luciferase coding sequence [2].
The potential role of RCI2A and RCI2B in plant development and stress response is discussed [1].
Furthermore, low temperatures are able to induce RCI2A and RCI2B expression in ABA-deficient and -insensitive genetic backgrounds, indicating that both ABA-dependent and -independent pathways regulate the low-temperature responsiveness of these two genes [3].

Biological context of RCI2A

RCI2A and RCI2B encode small (54 amino acids), highly hydrophobic proteins that bear two potential transmembrane domains [3].
Like most of the cold-inducible plant genes characterized, the expression of RCI2A and RCI2B is also promoted by abscisic acid (ABA) and dehydration but is not a general response to stress conditions, since it is not induced by salt stress or by anaerobiosis [3].
In this paper, we have investigated whether the lack of RCI2A gene, homologous to PMP3 gene, causes a salt sensitive phenotype in Arabidopsis (Arabidopsis thaliana (L.) Heynh.) plants; and to thereby indicate the physiological role of RCI2A in higher plants [4].

Associations of RCI2A with chemical compounds

The RCI2A transcript accumulated primarily in response to low temperature or high salinity, and to a lesser extent in response to ABA treatment or water deficit stress [5].

References

Developmental and stress regulation of RCI2A and RCI2B, two cold-inducible genes of arabidopsis encoding highly conserved hydrophobic proteins. Medina, J., Catalá, R., Salinas, J. Plant Physiol. (2001) [Pubmed]
Arabidopsis mutants deregulated in RCI2A expression reveal new signaling pathways in abiotic stress responses. Medina, J., Rodríguez-Franco, M., Peñalosa, A., Carrascosa, M.J., Neuhaus, G., Salinas, J. Plant J. (2005) [Pubmed]
Two homologous low-temperature-inducible genes from Arabidopsis encode highly hydrophobic proteins. Capel, J., Jarillo, J.A., Salinas, J., Martínez-Zapater, J.M. Plant Physiol. (1997) [Pubmed]
Disruption of RCI2A leads to over-accumulation of Na+ and increased salt sensitivity in Arabidopsis thaliana plants. Mitsuya, S., Taniguchi, M., Miyake, H., Takabe, T. Planta (2005) [Pubmed]
The low-temperature- and salt-induced RCI2A gene of Arabidopsis complements the sodium sensitivity caused by a deletion of the homologous yeast gene SNA1. Nylander, M., Heino, P., Helenius, E., Palva, E.T., Ronne, H., Welin, B.V. Plant Mol. Biol. (2001) [Pubmed]

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