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Gene Review:

BR6OX2 - brassinosteroid-6-oxidase 2

Arabidopsis thaliana

Synonyms: CYP85A2

Kim, T.W. et al., Castle, J. et al., Bancoş, S. et al.

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High impact information on BR6OX2/CYP85A2

This indicated that CYP85A2 is a bifunctional enzyme that possesses BR C-6 oxidase and BL synthase activity [1].
Arabidopsis CYP85A2, a cytochrome P450, mediates the Baeyer-Villiger oxidation of castasterone to brassinolide in brassinosteroid biosynthesis [1].
Biochemical, physiological, and molecular genetic analyses of Arabidopsis CYP85A2 loss-of-function and overexpression lines demonstrated that CS has to be a bioactive BR that controls the overall growth and development of Arabidopsis plants [1].
Feedback control of the CYP90C1, CYP90D1, and CYP85A2 genes by brassinolide suggests that the corresponding enzymes might also participate in BR synthesis [2].
To gain insight into potential sites of BR synthesis, we studied promoter activities of the two Arabidopsis BR C-6 oxidase genes (CYP85A1 and CYP85A2) in transgenic plants carrying promoter fusions with the GUS, GFP or LUC reporter genes [3].

Biological context of BR6OX2/CYP85A2

Comparison of the 5'-UTR and TATA box sequences of CYP85A1 and CYP85A2 revealed high homology, indicating a relatively recent gene duplication [3].

References

Arabidopsis CYP85A2, a cytochrome P450, mediates the Baeyer-Villiger oxidation of castasterone to brassinolide in brassinosteroid biosynthesis. Kim, T.W., Hwang, J.Y., Kim, Y.S., Joo, S.H., Chang, S.C., Lee, J.S., Takatsuto, S., Kim, S.K. Plant Cell (2005) [Pubmed]
Regulation of transcript levels of the Arabidopsis cytochrome p450 genes involved in brassinosteroid biosynthesis. Bancoş, S., Nomura, T., Sato, T., Molnár, G., Bishop, G.J., Koncz, C., Yokota, T., Nagy, F., Szekeres, M. Plant Physiol. (2002) [Pubmed]
Unique and overlapping expression patterns of Arabidopsis CYP85 genes involved in brassinosteroid C-6 oxidation. Castle, J., Szekeres, M., Jenkins, G., Bishop, G.J. Plant Mol. Biol. (2005) [Pubmed]

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