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Gene Review

ACX4  -  acyl-coenzyme A oxidase 4

Arabidopsis thaliana

Synonyms: ATG6, ATSCX, SHORT-CHAIN ACYL COA OXIDASE, acyl-CoA oxidase 4
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Disease relevance of ACX4


High impact information on ACX4


Biological context of ACX4

  • The acx3 and acx4 mutants were crossed together, and remarkably, the acx3acx4 double mutants aborted during the first phase of embryo development [3].

Analytical, diagnostic and therapeutic context of ACX4

  • Freshly prepared acyl-CoA oxidase 4 crystals diffract to 3.9 angstroms at cryogenic temperature at beamline I711, Max-Lab, but the diffraction quality degenerates after storage for only a few days in the crystallization drop [4].


  1. A novel acyl-CoA oxidase that can oxidize short-chain acyl-CoA in plant peroxisomes. Hayashi, H., De Bellis, L., Ciurli, A., Kondo, M., Hayashi, M., Nishimura, M. J. Biol. Chem. (1999) [Pubmed]
  2. Controlling Electron Transfer in Acyl-CoA Oxidases and Dehydrogenases: A STRUCTURAL VIEW. Mackenzie, J., Pedersen, L., Arent, S., Henriksen, A. J. Biol. Chem. (2006) [Pubmed]
  3. Arabidopsis mutants in short- and medium-chain acyl-CoA oxidase activities accumulate acyl-CoAs and reveal that fatty acid beta-oxidation is essential for embryo development. Rylott, E.L., Rogers, C.A., Gilday, A.D., Edgell, T., Larson, T.R., Graham, I.A. J. Biol. Chem. (2003) [Pubmed]
  4. Expression, purification and crystallization of two peroxisomal acyl-CoA oxidases from Arabidopsis thaliana. Pedersen, L., Henriksen, A. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
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