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Gene Review:

ACX3 - acyl-coenzyme A oxidase 3

Arabidopsis thaliana

Synonyms: ATACX3, acyl-CoA oxidase 3

Rylott, E.L. et al., Eastmond, P.J. et al., Froman, B.E. et al., Adham, A.R. et al.

Froman, Edwards, Bursch, Dehesh,

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Disease relevance of ACX3

AtACX3 was cloned and expressed in Escherichia coli [1].

High impact information on ACX3

A mutant in medium-chain length acyl-CoA activity (acx3) (1) shows a similar phenotype to acx4, and we show here that acx3 seedlings accumulate medium-chain length acyl-CoAs (16.4 mol %) [2].
Arabidopsis mutants in short- and medium-chain acyl-CoA oxidase activities accumulate acyl-CoAs and reveal that fatty acid beta-oxidation is essential for embryo development [2].
After the discovery of AtACX3, the Arabidopsis acyl-CoA oxidase gene family now comprises four isozymes with substrate specificities that encompass the full range of acyl-CoA chain lengths that exist in vivo [1].
The temporal and spatial expression patterns of AtACX3 during development and in various tissues were similar to those of the AtSACX and other genes expressed in glyoxysomes [3].

Other interactions of ACX3

We used positional cloning to determine that one mutant is defective in ACX1 and two are defective in ACX3, two of the six Arabidopsis fatty acyl-CoA oxidase (ACX) genes [4].
The acx3 and acx4 mutants were crossed together, and remarkably, the acx3acx4 double mutants aborted during the first phase of embryo development [2].

References

Promoter trapping of a novel medium-chain acyl-CoA oxidase, which is induced transcriptionally during Arabidopsis seed germination. Eastmond, P.J., Hooks, M.A., Williams, D., Lange, P., Bechtold, N., Sarrobert, C., Nussaume, L., Graham, I.A. J. Biol. Chem. (2000) [Pubmed]
Arabidopsis mutants in short- and medium-chain acyl-CoA oxidase activities accumulate acyl-CoAs and reveal that fatty acid beta-oxidation is essential for embryo development. Rylott, E.L., Rogers, C.A., Gilday, A.D., Edgell, T., Larson, T.R., Graham, I.A. J. Biol. Chem. (2003) [Pubmed]
ACX3, a novel medium-chain acyl-coenzyme A oxidase from Arabidopsis. Froman, B.E., Edwards, P.C., Bursch, A.G., Dehesh, K. Plant Physiol. (2000) [Pubmed]
Mutations in Arabidopsis acyl-CoA oxidase genes reveal distinct and overlapping roles in beta-oxidation. Adham, A.R., Zolman, B.K., Millius, A., Bartel, B. Plant J. (2005) [Pubmed]

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