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Gene Review

CRD1  -  magnesium-protoporphyrin IX monomethyl...

Arabidopsis thaliana

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Disease relevance of AT103

  • The Crd1 gene encodes a putative di-iron enzyme required for photosystem I accumulation in copper deficiency and hypoxia in Chlamydomonas reinhardtii [1].

High impact information on AT103

  • Loss-of-function mutations in these genes have a phenotype similar to that of mutations in the Argonaute gene ZIPPY (ZIP) [2].
  • Crd1 homologs are present in the genomes of photosynthetic organisms [1].
  • The crd strains represent alleles at a single locus, CRD1, which encodes a 47 kDa, hydrophilic protein with a consensus carboxylate-bridged di-iron binding site [1].
  • The Xantha-l gene, corresponding to Arabidopsis thaliana CHL27, Rubrivivax gelatinosus acsF, Chlamydomonas reinhardtii CRD1, and CTH1 and situated at the short arm of barley chromosome 3 (3H), was cloned, and the mutations in xantha-l(35), xantha-l(81), and xantha-l(82) were characterized [3].
  • Fractionation of Arabidopsis chloroplast membranes shows that Crd1/CHL27 is equally distributed on a membrane-weight basis in the thylakoid and inner-envelope membranes [4].

Anatomical context of AT103


Analytical, diagnostic and therapeutic context of AT103


  1. The Crd1 gene encodes a putative di-iron enzyme required for photosystem I accumulation in copper deficiency and hypoxia in Chlamydomonas reinhardtii. Moseley, J., Quinn, J., Eriksson, M., Merchant, S. EMBO J. (2000) [Pubmed]
  2. SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis. Peragine, A., Yoshikawa, M., Wu, G., Albrecht, H.L., Poethig, R.S. Genes Dev. (2004) [Pubmed]
  3. Xantha-l encodes a membrane subunit of the aerobic Mg-protoporphyrin IX monomethyl ester cyclase involved in chlorophyll biosynthesis. Rzeznicka, K., Walker, C.J., Westergren, T., Kannangara, C.G., von Wettstein, D., Merchant, S., Gough, S.P., Hansson, M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Arabidopsis CHL27, located in both envelope and thylakoid membranes, is required for the synthesis of protochlorophyllide. Tottey, S., Block, M.A., Allen, M., Westergren, T., Albrieux, C., Scheller, H.V., Merchant, S., Jensen, P.E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  5. Comparative microarray analysis of Arabidopsis thaliana and Arabidopsis halleri roots identifies nicotianamine synthase, a ZIP transporter and other genes as potential metal hyperaccumulation factors. Weber, M., Harada, E., Vess, C., Roepenack-Lahaye, E., Clemens, S. Plant J. (2004) [Pubmed]
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