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Gene Review

APX4  -  ascorbate peroxidase 4

Arabidopsis thaliana

Synonyms: F23J3.40, F23J3_40, TL29, thylakoid lumen 29
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High impact information on APX4

  • By employing tDNA insertion mutants of A. thaliana lacking expression of AtprxII F (KO-AtPrxII F), it is shown that under optimal environmental conditions the absence of PrxII F is almost fully compensated for, possibly by increases in activity of mitochondrial ascorbate peroxidase and glutathione-dependent peroxidase [1].
  • In an in vitro test system, they all showed peroxidase activity, but could be distinguished by their ability to accept dithiothreitol and thioredoxin as electron donor in the regeneration reaction [2].
  • Measurements of other antioxidants revealed an increase in ascorbate- and pyrogallol-dependent peroxidase activity in low-ascorbate lines [3].
  • A peroxidase homologue and novel plastocyanin located by proteomics to the Arabidopsis chloroplast thylakoid lumen [4].
  • The thioredoxin-dependent peroxidase activity can be measured in crude plant extracts and contributes significantly to the overall H(2)O(2) detoxification capacity [5].

Biological context of APX4


Associations of APX4 with chemical compounds


  1. The mitochondrial type II peroxiredoxin F is essential for redox homeostasis and root growth of Arabidopsis thaliana under stress. Finkemeier, I., Goodman, M., Lamkemeyer, P., Kandlbinder, A., Sweetlove, L.J., Dietz, K.J. J. Biol. Chem. (2005) [Pubmed]
  2. Divergent light-, ascorbate-, and oxidative stress-dependent regulation of expression of the peroxiredoxin gene family in Arabidopsis. Horling, F., Lamkemeyer, P., König, J., Finkemeier, I., Kandlbinder, A., Baier, M., Dietz, K.J. Plant Physiol. (2003) [Pubmed]
  3. Antisense suppression of l-galactose dehydrogenase in Arabidopsis thaliana provides evidence for its role in ascorbate synthesis and reveals light modulated l-galactose synthesis. Gatzek, S., Wheeler, G.L., Smirnoff, N. Plant J. (2002) [Pubmed]
  4. A peroxidase homologue and novel plastocyanin located by proteomics to the Arabidopsis chloroplast thylakoid lumen. Kieselbach, T., Bystedt, M., Hynds, P., Robinson, C., Schröder, W.P. FEBS Lett. (2000) [Pubmed]
  5. The function of peroxiredoxins in plant organelle redox metabolism. Dietz, K.J., Jacob, S., Oelze, M.L., Laxa, M., Tognetti, V., de Miranda, S.M., Baier, M., Finkemeier, I. J. Exp. Bot. (2006) [Pubmed]
  6. Ascorbic acid in plants: biosynthesis and function. Smirnoff, N., Wheeler, G.L. Crit. Rev. Biochem. Mol. Biol. (2000) [Pubmed]
  7. Cloning and sequencing of a cDNA encoding ascorbate peroxidase from Arabidopsis thaliana. Kubo, A., Saji, H., Tanaka, K., Tanaka, K., Kondo, N. Plant Mol. Biol. (1992) [Pubmed]
  8. Ascorbate biosynthesis and function in photoprotection. Smirnoff, N. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (2000) [Pubmed]
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