Disease relevance of PDX1

• The revelation is based on the recent discovery that, in bacteria and fungi, a novel pathway is in place that involves two genes (PDX1 and PDX2), neither of which is homologous to any of those involved in the previously doctrined E. coli pathway [1].

High impact information on PDX1

• In this study, an Arabidopsis pyridoxine synthase gene PDX1 was characterized and its in vivo functions were investigated [2].
• The PDX1 protein was mainly associated with the plasma membrane and endomembranes, implying a potential involvement of vitamin B6 in membrane function [2].
• In addition to the developmental defects, pdx1 mutants are hypersensitive to osmotic stress and oxidative stress [2].
• In roots, PDX1 was highly expressed in a defined region behind the root tips that undergoes rapid cell division [2].
• The PDX1 gene was expressed in all plant parts examined and its expression level was not significantly regulated by abiotic stress or the phytohormone abscisic acid [2].

Biological context of PDX1

• Arabidopsis thaliana contains one copy of PDX2, but three full-length copies of PDX1, one each on chromosomes 2, 3, and 5 (referred to as PDX1.1, PDX1.2, and PDX1.3, respectively) [3].

Anatomical context of PDX1

• Green fluorescent protein fusion studies demonstrated that PDX2 localizes in the nucleus and membranes of cells, consistent with recent published data for PDX1 [3].

References