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Gene Review

SNZ1  -  pyridoxine biosynthesis protein SNZ1

Saccharomyces cerevisiae S288c

Synonyms: PDX1 homolog 1, PLP synthase subunit SNZ1, Pdx1.1, Pyridoxal 5'-phosphate synthase subunit SNZ1, YM6543.03, ...
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Disease relevance of SNZ1

  • In order to clarify their function, the two genes SNO1 and SNZ1 were expressed in Escherichia coli either individually or simultaneously and with or without a His-tag [1].
  • The broad phylogenetic distribution, the regulation of the SNZ1 mRNA and protein in S. cerevisiae, and identification of a Snz protein modified during sporulation in the gram-positive bacterium Bacillus subtilis support the hypothesis that Snz proteins are part of an ancient response that occurs during nutrient limitation and growth arrest [2].
  • However, DRONC activity is not suppressed by the caspase inhibitor and cell death suppressor baculovirus p35 [3].

High impact information on SNZ1

  • Interestingly, Swp73p is necessary for efficient SWI/SNF recruitment at SNZ1 but not at ARG1, indicating distinct subunit requirements for SWI/SNF recruitment at different genes [4].
  • We also provide evidence that of the highly conserved SNZ and SNO genes in S. cerevisiae, only the protein encoded by SNZ1 is required for vitamin B6 biosynthesis [5].
  • We report the analysis of a 36-kbp region of the Neurospora crassa genome, which contains homologs of two closely linked stationary phase genes, SNZ1 and SNO1, from Saccharomyces cerevisiae [6].
  • Homologs of SNZ1 encode extremely highly conserved proteins that have been implicated in pyridoxine (vitamin B6) metabolism in the filamentous fungi Cercospora nicotianae and in Aspergillus nidulans [6].
  • In snz2 snz3 mutants, SNZ1 mRNA is induced prior to the diauxic shift, when SNZ2/3 mRNAs are normally induced [7].

Biological context of SNZ1

  • A close match to the 9/11 bases of the ARS consensus sequence was sufficient for p35 binding activity [8].

Associations of SNZ1 with chemical compounds

  • Under nitrogen-limiting conditions, SNZ1 mRNAs accumulate in tryptophan, adenine, and uracil auxotrophs but not in prototrophic strains, indicating that induction occurs in response to the limitation of specific nutrients [7].
  • Strains carrying deletions in all SNZ-SNO gene pairs are viable, but snz1 and sno1 mutants are sensitive to 6-azauracil (6-AU), an inhibitor of purine and pyrimidine biosynthetic enzymes, and methylene blue, a producer of singlet oxygen [7].
  • Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae [1].
  • We detected increased SNZ1 mRNA accumulation almost 2 days after glucose exhaustion, significantly later than that of mRNAs encoded by other postexponential genes [2].

Analytical, diagnostic and therapeutic context of SNZ1

  • Using real-time RT-PCR (RT-RTPCR), increased peak expression of both SNZ1 and SNO1 was observed at 5 and 6 days, respectively, in C. albicans grown in suspension culture [9].
  • All three mutants accumulate novel proteins of 35 and 44 kDa (p35 and p44, respectively) detected both by labeling of mitochondrial translation products and by Western blotting [10].


  1. Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae. Dong, Y.X., Sueda, S., Nikawa, J., Kondo, H. Eur. J. Biochem. (2004) [Pubmed]
  2. A stationary-phase gene in Saccharomyces cerevisiae is a member of a novel, highly conserved gene family. Braun, E.L., Fuge, E.K., Padilla, P.A., Werner-Washburne, M. J. Bacteriol. (1996) [Pubmed]
  3. The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM. Hawkins, C.J., Yoo, S.J., Peterson, E.P., Wang, S.L., Vernooy, S.Y., Hay, B.A. J. Biol. Chem. (2000) [Pubmed]
  4. Recruitment of SWI/SNF by Gcn4p does not require Snf2p or Gcn5p but depends strongly on SWI/SNF integrity, SRB mediator, and SAGA. Yoon, S., Qiu, H., Swanson, M.J., Hinnebusch, A.G. Mol. Cell. Biol. (2003) [Pubmed]
  5. Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae. Stolz, J., Vielreicher, M. J. Biol. Chem. (2003) [Pubmed]
  6. Analysis of the pdx-1 (snz-1/sno-1) region of the Neurospora crassa genome: correlation of pyridoxine-requiring phenotypes with mutations in two structural genes. Bean, L.E., Dvorachek, W.H., Braun, E.L., Errett, A., Saenz, G.S., Giles, M.D., Werner-Washburne, M., Nelson, M.A., Natvig, D.O. Genetics (2001) [Pubmed]
  7. The highly conserved, coregulated SNO and SNZ gene families in Saccharomyces cerevisiae respond to nutrient limitation. Padilla, P.A., Fuge, E.K., Crawford, M.E., Errett, A., Werner-Washburne, M. J. Bacteriol. (1998) [Pubmed]
  8. A approximately 35 kDa polypeptide from insect cells binds to yeast ACS like elements in the presence of ATP. Dhar, S.K., Mondal, N., Soni, R.K., Mukhopadhyay, G. BMC Biochem. (2002) [Pubmed]
  9. Candida albicans SNO1 and SNZ1 expressed in stationary-phase planktonic yeast cells and base of biofilm. Uppuluri, P., Sarmah, B., Chaffin, W.L. Microbiology (Reading, Engl.) (2006) [Pubmed]
  10. The mobile group I intron 3 alpha of the yeast mitochondrial COXI gene encodes a 35-kDa processed protein that is an endonuclease but not a maturase. Guo, W.W., Moran, J.V., Hoffman, P.W., Henke, R.M., Butow, R.A., Perlman, P.S. J. Biol. Chem. (1995) [Pubmed]
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