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Gene Review

Acox3  -  acyl-CoA oxidase 3, pristanoyl

Rattus norvegicus

Synonyms: BRCACox, Branched-chain acyl-CoA oxidase, Peroxisomal acyl-coenzyme A oxidase 3, Prcox, Pristanoyl-CoA oxidase
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High impact information on Acox3


Anatomical context of Acox3

  • Screening of different rat tissues, either for enzyme activity or by immunoblotting, revealed the highest level of pristanoyl-CoA oxidase in liver, followed by kidney, intestinal mucosa, spleen and lung [4].

Associations of Acox3 with chemical compounds


Other interactions of Acox3


Analytical, diagnostic and therapeutic context of Acox3

  • This was also confirmed by immunoblotting which provided a clear signal only in rat liver, possibly indicating that pristanoyl-CoA oxidase might be a rat-specific oxidase [4].


  1. Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase. Van Veldhoven, P.P., Vanhove, G., Assselberghs, S., Eyssen, H.J., Mannaerts, G.P. J. Biol. Chem. (1992) [Pubmed]
  2. Studies on the effect of fenoprofen on the activation and oxidation of long chain and very long chain fatty acids in hepatocytes and subcellular fractions from rat liver. Lageweg, W., Wanders, R.J. Biochem. Pharmacol. (1993) [Pubmed]
  3. Rat pristanoyl-CoA oxidase. cDNA cloning and recognition of its C-terminal (SQL) by the peroxisomal-targeting signal 1 receptor. Vanhooren, J.C., Fransen, M., de Béthune, B., Baumgart, E., Baes, M., Torrekens, S., Van Leuven, F., Mannaerts, G.P., Van Veldhoven, P.P. Eur. J. Biochem. (1996) [Pubmed]
  4. Large-scale purification and further characterization of rat pristanoyl-CoA oxidase. Van Veldhoven, P.P., Van Rompuy, P., Fransen, M., De Béthune, B., Mannaerts, G.P. Eur. J. Biochem. (1994) [Pubmed]
  5. Role and organization of peroxisomal beta-oxidation. Van Veldhoven, P.P., Mannaerts, G.P. Adv. Exp. Med. Biol. (1999) [Pubmed]
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