The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

MYB34  -  myb domain protein 34

Arabidopsis thaliana

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ATR1


High impact information on ATR1

  • Thus, ATR1 defines the first characterized tryptophan gene regulator in plants, and the atr1D mutation defines a sequence important for ATR1 expression [2].
  • A Myb homologue, ATR1, activates tryptophan gene expression in Arabidopsis [2].
  • The ATR1 transcript also includes a 5' regulatory region with three short ORFs, one of which is prematurely terminated by the atr1D mutation [2].
  • ATR1 encodes a protein of 692 amino acids, while ATR2 encodes either a 712-residue protein (ATR2-1), or a 702-residue protein (ATR2-2) depending on the choice of the initiation codon [3].
  • Biochemical characterization of the Arabidopsis ATR1/CYP73A5 and ATR2-1/CYP73A5 systems demonstrates that the two distantly related Arabidopsis reductases similarly support the first oxidative step of the phenylpropanoid general pathway [3].

Biological context of ATR1


Associations of ATR1 with chemical compounds

  • Here, we show that ATR1 overexpression confers elevated levels of IAA and IGs [4].


  1. CYP79B1 from Sinapis alba converts tryptophan to indole-3-acetaldoxime. Naur, P., Hansen, C.H., Bak, S., Hansen, B.G., Jensen, N.B., Nielsen, H.L., Halkier, B.A. Arch. Biochem. Biophys. (2003) [Pubmed]
  2. A Myb homologue, ATR1, activates tryptophan gene expression in Arabidopsis. Bender, J., Fink, G.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-cytochrome P450 reductases with P450 CYP73A5. Urban, P., Mignotte, C., Kazmaier, M., Delorme, F., Pompon, D. J. Biol. Chem. (1997) [Pubmed]
  4. The Arabidopsis ATR1 Myb transcription factor controls indolic glucosinolate homeostasis. Celenza, J.L., Quiel, J.A., Smolen, G.A., Merrikh, H., Silvestro, A.R., Normanly, J., Bender, J. Plant Physiol. (2005) [Pubmed]
WikiGenes - Universities