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Gene Review

MYB34  -  myb domain protein 34

Arabidopsis thaliana

Synonyms: ALTERED TRYPTOPHAN REGULATION 1, ATMYB34, ATR1, MSL3.10, MSL3_10
 
 
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Disease relevance of ATR1

 

High impact information on ATR1

  • Thus, ATR1 defines the first characterized tryptophan gene regulator in plants, and the atr1D mutation defines a sequence important for ATR1 expression [2].
  • A Myb homologue, ATR1, activates tryptophan gene expression in Arabidopsis [2].
  • The ATR1 transcript also includes a 5' regulatory region with three short ORFs, one of which is prematurely terminated by the atr1D mutation [2].
  • ATR1 encodes a protein of 692 amino acids, while ATR2 encodes either a 712-residue protein (ATR2-1), or a 702-residue protein (ATR2-2) depending on the choice of the initiation codon [3].
  • Biochemical characterization of the Arabidopsis ATR1/CYP73A5 and ATR2-1/CYP73A5 systems demonstrates that the two distantly related Arabidopsis reductases similarly support the first oxidative step of the phenylpropanoid general pathway [3].
 

Biological context of ATR1

 

Associations of ATR1 with chemical compounds

  • Here, we show that ATR1 overexpression confers elevated levels of IAA and IGs [4].

References

  1. CYP79B1 from Sinapis alba converts tryptophan to indole-3-acetaldoxime. Naur, P., Hansen, C.H., Bak, S., Hansen, B.G., Jensen, N.B., Nielsen, H.L., Halkier, B.A. Arch. Biochem. Biophys. (2003) [Pubmed]
  2. A Myb homologue, ATR1, activates tryptophan gene expression in Arabidopsis. Bender, J., Fink, G.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-cytochrome P450 reductases with P450 CYP73A5. Urban, P., Mignotte, C., Kazmaier, M., Delorme, F., Pompon, D. J. Biol. Chem. (1997) [Pubmed]
  4. The Arabidopsis ATR1 Myb transcription factor controls indolic glucosinolate homeostasis. Celenza, J.L., Quiel, J.A., Smolen, G.A., Merrikh, H., Silvestro, A.R., Normanly, J., Bender, J. Plant Physiol. (2005) [Pubmed]
 
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