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Gene Review:

F2KP - 6-phosphofructo-2-kinase/fructose-2,6...

Arabidopsis thaliana

Synonyms: "fructose-2,6-bisphosphatase", 6-BISPHOSPHATASE, 6-bisphosphatase, ATF2KP, F10K1.19, ...

Villadsen, D. et al., Villadsen, D. et al., Kulma, A. et al.

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Disease relevance of F2KP

AtF2KP was expressed in Escherichia coli as a full length and a truncated (without the NH(2)-terminal region) fusion protein [1].

High impact information on F2KP

Nevertheless, our findings indicate the possibility that 14-3-3 binding to SnRK1-phosphorylated sites on NR and F2KP may regulate both nitrate assimilation and sucrose/starch partitioning in leaves [2].
Phosphorylation and 14-3-3 binding of Arabidopsis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase [2].
N-terminal truncation affects the kinetics and structure of fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase from Arabidopsis thaliana [3].
The enzyme fructose-6-phosphate 2-kinase (F6P,2K; 6-phosphofructo-2-kinase)/fructose-2,6-bisphosphatase (F26BPase) catalyses the formation and degradation of the regulatory metabolite fructose 2,6-bisphosphate [3].
A full-length cDNA clone encoding fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase from Arabidopsis thaliana (AtF2KP) was isolated [1].

Analytical, diagnostic and therapeutic context of F2KP

Western blots show that F2KP from several plant species migrates in sodium dodecyl sulphate-polyacrylamide gel electrophoresis as a similar sized (93 kDa) protein [1].

References

Structure and heterologous expression of a gene encoding fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase from Arabidopsis thaliana. Villadsen, D., Rung, J.H., Draborg, H., Nielsen, T.H. Biochim. Biophys. Acta (2000) [Pubmed]
Phosphorylation and 14-3-3 binding of Arabidopsis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Kulma, A., Villadsen, D., Campbell, D.G., Meek, S.E., Harthill, J.E., Nielsen, T.H., MacKintosh, C. Plant J. (2004) [Pubmed]
N-terminal truncation affects the kinetics and structure of fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase from Arabidopsis thaliana. Villadsen, D., Nielsen, T.H. Biochem. J. (2001) [Pubmed]

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