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Gene Review

PFKFB4  -  6-phosphofructo-2-kinase/fructose-2,6...

Homo sapiens

Synonyms: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6PF-2-K/Fru-2,6-P2ase 4, 6PF-2-K/Fru-2,6-P2ase testis-type isozyme, PFK/FBPase 4
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Disease relevance of PFKFB4


High impact information on PFKFB4


Chemical compound and disease context of PFKFB4


Biological context of PFKFB4


Anatomical context of PFKFB4


Regulatory relationships of PFKFB4


Other interactions of PFKFB4

  • In order to investigate the mechanisms of hypoxic regulation of PFKFB4 gene expression, we used dimethyloxalylglycine, which has the ability to mimic effect of hypoxia by significant induction of hypoxia-inducible factor (HIF-1alpha) protein levels [1].
  • The basal level of PFKFB-4 protein expression in gastric cancers was much higher as compared to the PFKFB-3 isoenzyme [4].

Analytical, diagnostic and therapeutic context of PFKFB4


  1. Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation. Minchenko, O., Opentanova, I., Minchenko, D., Ogura, T., Esumi, H. FEBS Lett. (2004) [Pubmed]
  2. Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines. Minchenko, O.H., Opentanova, I.L., Ogura, T., Minchenko, D.O., Komisarenko, S.V., Caro, J., Esumi, H. Acta Biochim. Pol. (2005) [Pubmed]
  3. Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation. Minchenko, O.H., Ogura, T., Opentanova, I.L., Minchenko, D.O., Esumi, H. Mol. Cell. Biochem. (2005) [Pubmed]
  4. Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers. Bobarykina, A.Y., Minchenko, D.O., Opentanova, I.L., Moenner, M., Caro, J., Esumi, H., Minchenko, O.H. Acta Biochim. Pol. (2006) [Pubmed]
  5. Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy. Kim, S.G., Manes, N.P., El-Maghrabi, M.R., Lee, Y.H. J. Biol. Chem. (2006) [Pubmed]
  6. Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5'-flanking region. Gómez, M., Manzano, A., Navarro-Sabaté, A., Duran, J., Obach, M., Perales, J.C., Bartrons, R. FEBS Lett. (2005) [Pubmed]
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