The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

PFKFB4  -  6-phosphofructo-2-kinase/fructose-2,6...

Homo sapiens

Synonyms: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6PF-2-K/Fru-2,6-P2ase 4, 6PF-2-K/Fru-2,6-P2ase testis-type isozyme, PFK/FBPase 4
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of PFKFB4

 

High impact information on PFKFB4

 

Chemical compound and disease context of PFKFB4

 

Biological context of PFKFB4

 

Anatomical context of PFKFB4

 

Regulatory relationships of PFKFB4

 

Other interactions of PFKFB4

  • In order to investigate the mechanisms of hypoxic regulation of PFKFB4 gene expression, we used dimethyloxalylglycine, which has the ability to mimic effect of hypoxia by significant induction of hypoxia-inducible factor (HIF-1alpha) protein levels [1].
  • The basal level of PFKFB-4 protein expression in gastric cancers was much higher as compared to the PFKFB-3 isoenzyme [4].
 

Analytical, diagnostic and therapeutic context of PFKFB4

References

  1. Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation. Minchenko, O., Opentanova, I., Minchenko, D., Ogura, T., Esumi, H. FEBS Lett. (2004) [Pubmed]
  2. Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines. Minchenko, O.H., Opentanova, I.L., Ogura, T., Minchenko, D.O., Komisarenko, S.V., Caro, J., Esumi, H. Acta Biochim. Pol. (2005) [Pubmed]
  3. Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation. Minchenko, O.H., Ogura, T., Opentanova, I.L., Minchenko, D.O., Esumi, H. Mol. Cell. Biochem. (2005) [Pubmed]
  4. Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers. Bobarykina, A.Y., Minchenko, D.O., Opentanova, I.L., Moenner, M., Caro, J., Esumi, H., Minchenko, O.H. Acta Biochim. Pol. (2006) [Pubmed]
  5. Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy. Kim, S.G., Manes, N.P., El-Maghrabi, M.R., Lee, Y.H. J. Biol. Chem. (2006) [Pubmed]
  6. Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5'-flanking region. Gómez, M., Manzano, A., Navarro-Sabaté, A., Duran, J., Obach, M., Perales, J.C., Bartrons, R. FEBS Lett. (2005) [Pubmed]
 
WikiGenes - Universities