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Gene Review

TSSK6  -  testis-specific serine kinase 6

Homo sapiens

Synonyms: CT72, Cancer/testis antigen 72, FKSG82, FLJ24002, SSTK, ...
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Disease relevance of TSSK6


High impact information on TSSK6

  • A defect in DNA condensation in SSTK null mutants occurred in elongating spermatids at a step in spermiogenesis coincident with chromatin displacement of histones by transition proteins [1].
  • The SSTK transcript was most abundant in human and mouse testes but was also detected in all human tissues tested [1].
  • Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility [1].
  • These results demonstrate that SSTK is required for proper postmeiotic chromatin remodeling and male fertility [1].
  • Here we describe and characterize a small serine/threonine kinase (SSTK) which consists solely of the N- and C-lobes of a protein kinase catalytic domain [1].

Biological context of TSSK6

  • SSTK protein is highly conserved among mammals, and no close homologues were found in the genomes of nonmammalian organisms [1].


  1. Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. Spiridonov, N.A., Wong, L., Zerfas, P.M., Starost, M.F., Pack, S.D., Paweletz, C.P., Johnson, G.R. Mol. Cell. Biol. (2005) [Pubmed]
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