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MESDC2  -  mesoderm development candidate 2

Homo sapiens

Synonyms: BOCA, KIAA0081, LDLR chaperone MESD, MESD, Mesoderm development candidate 2, ...
 
 
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Disease relevance of MESDC2

  • A possible structural and functional organization of the antenna chromophore protein complexes (CPC) in the Rhodopseudomonas viridis membranes was considered in terms of structural models proposed by Zuber and Brunisholz (in Chlorophylls, ed. H. Scheer (Boca Raton: CRC Press, 1991):626-703) [1].
 

High impact information on MESDC2

  • Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity [2].
  • Disruption of embryonic polarity and mesoderm differentiation in mesd-deficient embryos likely results from a primary defect in WNT signaling [2].
  • Both reciprocal SENP1-MESDC2 (SEME) and MESDC2-SENP1 (MESE) fusion genes are transcribed in tumor-derived cells and their open reading frames encode aberrant proteins [3].
  • We also found that LRP6 is not a constitutively active endocytosis receptor and binding of the receptor-associated protein to LRP6 partially competes for Mesd binding [4].
  • Smith and Williams' Introduction to the Principles of Drug Design and Action. Fourth Edition Edited by H. John Smith. CRC/Taylor and Francis, Boca Raton, FL. 2006. xvi + 658 pp. 18.5 x 26 cm. ISBN-13 978-0-415-28877-4. $139.95 [5].
 

Biological context of MESDC2

 

Anatomical context of MESDC2

  • As a consequence of this, and in contrast to wild-type (WT) MESDC2, the translocation-associated SEME protein is no longer targeted to the endoplasmatic reticulum, leading to a presumed loss-of-function as a chaperone for the WNT co-receptors LRP5 and/or LRP6 [3].
  • Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 [8].
 

Associations of MESDC2 with chemical compounds

  • Del Boca; "Using Interactive Voice Response Technology to Assess the Alcohol-Victimization Link" by Kathleen Parks, Linda King, and Ann Pardi; "Methodological Issues in Using Personal Data Assistants to Self-monitor Alcohol Consumption" by R [9].
  • In the microdialysis study, the striatal extracellular level of dopamine (DA) markedly increased (144-fold) immediately after BOCA [10].
  • Buffered papaverine facilitates passage of intratympanic dexamethasone to the inner earThis study was accepted as an oral presentation by the American Neurotology Society, Spring Meeting, Boca Raton, FL, USA, 14-15 May 2005 [11].
 

Analytical, diagnostic and therapeutic context of MESDC2

  • Using comparative mapping and genomic sequence analysis, we have identified four novel genes and Il16 in the mesd deletion interval [6].

References

  1. The structural organization of the antenna chromophore protein complexes in membranes of the photosynthetic bacterium Rhodopseudomonas viridis. Klevanik, A.V. Membrane & cell biology. (1998) [Pubmed]
  2. Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Hsieh, J.C., Lee, L., Zhang, L., Wefer, S., Brown, K., DeRossi, C., Wines, M.E., Rosenquist, T., Holdener, B.C. Cell (2003) [Pubmed]
  3. Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25). Veltman, I.M., Vreede, L.A., Cheng, J., Looijenga, L.H., Janssen, B., Schoenmakers, E.F., Yeh, E.T., van Kessel, A.G. Hum. Mol. Genet. (2005) [Pubmed]
  4. Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. Li, Y., Chen, J., Lu, W., McCormick, L.M., Wang, J., Bu, G. J. Cell. Sci. (2005) [Pubmed]
  5. Smith and Williams' Introduction to the Principles of Drug Design and Action. Fourth Edition Edited by H. John Smith. CRC/Taylor and Francis, Boca Raton, FL. 2006. xvi + 658 pp. 18.5 x 26 cm. ISBN-13 978-0-415-28877-4. $139.95. Currie, B.L. J. Med. Chem. (2007) [Pubmed]
  6. Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. Wines, M.E., Lee, L., Katari, M.S., Zhang, L., DeRossi, C., Shi, Y., Perkins, S., Feldman, M., McCombie, W.R., Holdener, B.C. Genomics (2001) [Pubmed]
  7. Effect of pregnancy on the accuracy of light-reflection rheography. Allbert, J.R., Roberts, W.E., Hess, L.W., Morrison, J.C. Am. J. Obstet. Gynecol. (1991) [Pubmed]
  8. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. Nagase, T., Miyajima, N., Tanaka, A., Sazuka, T., Seki, N., Sato, S., Tabata, S., Ishikawa, K., Kawarabayasi, Y., Kotani, H. DNA Res. (1995) [Pubmed]
  9. Capturing the moment: innovative approaches to daily alcohol assessment. Neal, D.J., Fromme, K., Boca, F.K., Parks, K.A., King, L.P., Pardi, A.M., Collins, R.L., Muraven, M., Vetter, C., Corbin, W.R. Alcohol. Clin. Exp. Res. (2006) [Pubmed]
  10. Sustained increase in adrenergic activity in gerbil striatum following transient ischemia. Izumi, J., Inagaki, M., Kiuchi, Y., Matsumoto, M., Yamazaki, Y., Morioka, D., Usami, S., Oguchi, K. Jpn. J. Pharmacol. (1993) [Pubmed]
  11. Buffered papaverine facilitates passage of intratympanic dexamethasone to the inner earThis study was accepted as an oral presentation by the American Neurotology Society, Spring Meeting, Boca Raton, FL, USA, 14-15 May 2005. Naci Ozluoglu, L., Yilmaz, I., Akkuzu, B., Haberal, A. Acta Otolaryngol. (2006) [Pubmed]
 
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