Gene Review:
Fcgr2b - Fc receptor, IgG, low affinity IIb
Mus musculus
Synonyms:
AI528646, CD32, F630109E10Rik, Fc gamma RIIB, Fc gamma receptor IIB, ...
- Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. Bolland, S., Yim, Y.S., Tus, K., Wakeland, E.K., Ravetch, J.V. J. Exp. Med. (2002)
- Fc gamma Rs modulate cytotoxicity of anti-Fas antibodies: implications for agonistic antibody-based therapeutics. Xu, Y., Szalai, A.J., Zhou, T., Zinn, K.R., Chaudhuri, T.R., Li, X., Koopman, W.J., Kimberly, R.P. J. Immunol. (2003)
- FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease. Yajima, K., Nakamura, A., Sugahara, A., Takai, T. Eur. J. Immunol. (2003)
- Phenotypic properties of 3T3 cells transformed in vitro with polyoma virus and passaged once in syngeneic animals. Langer, A.B., Emmanuel, N., Even, J., Fridman, W.H., Gohar, O., Gonen, B., Katz, B.Z., Ran, M., Smorodinsky, N.I., Witz, I.P. Immunobiology (1992)
- Inhibition of a vaccine-induced anti-tumor B cell response by soluble protein antigen in the absence of continuing T cell help. Savelyeva, N., King, C.A., Vitetta, E.S., Stevenson, F.K. Proc. Natl. Acad. Sci. U.S.A. (2005)
- A population of early fetal thymocytes expressing Fc gamma RII/III contains precursors of T lymphocytes and natural killer cells. Rodewald, H.R., Moingeon, P., Lucich, J.L., Dosiou, C., Lopez, P., Reinherz, E.L. Cell (1992)
- A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation. Zhu, D., Kepley, C.L., Zhang, M., Zhang, K., Saxon, A. Nat. Med. (2002)
- Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Clynes, R.A., Towers, T.L., Presta, L.G., Ravetch, J.V. Nat. Med. (2000)
- A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling. Muta, T., Kurosaki, T., Misulovin, Z., Sanchez, M., Nussenzweig, M.C., Ravetch, J.V. Nature (1994)
- Potentiation of antiproliferative effects of monoclonal antibody Lym-1 and immunoconjugate Lym-1-gelonin on human Burkitt's lymphoma cells with gamma-interferon and tumor necrosis factor. O'Boyle, K.P., Colletti, D., Mazurek, C., Wang, Y., Ray, S.K., Diamond, B., Rosenblum, M.G., Epstein, A.L., Shochat, D., Dutcher, J.P. Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy. (1995)
- Cross-linking of IgG receptors inhibits membrane immunoglobulin-stimulated calcium influx in B lymphocytes. Choquet, D., Partiseti, M., Amigorena, S., Bonnerot, C., Fridman, W.H., Korn, H. J. Cell Biol. (1993)
- Maximum-tolerated dose, toxicity, and efficacy of (131)I-Lym-1 antibody for fractionated radioimmunotherapy of non-Hodgkin's lymphoma. DeNardo, G.L., DeNardo, S.J., Goldstein, D.S., Kroger, L.A., Lamborn, K.R., Levy, N.B., McGahan, J.P., Salako, Q., Shen, S., Lewis, J.P. J. Clin. Oncol. (1998)
- Characterization of anti-mouse Fc gamma RII single-chain Fv fragments derived from human phage display libraries. McCall, A.M., Amoroso, A.R., Sautès, C., Marks, J.D., Weiner, L.M. Immunotechnology (1998)
- Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus. Kikuchi, S., Santiago-Raber, M.L., Amano, H., Amano, E., Fossati-Jimack, L., Moll, T., Kotzin, B.L., Izui, S. J. Immunol. (2006)
- Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses. Xiu, Y., Nakamura, K., Abe, M., Li, N., Wen, X.S., Jiang, Y., Zhang, D., Tsurui, H., Matsuoka, S., Hamano, Y., Fujii, H., Ono, M., Takai, T., Shimokawa, T., Ra, C., Shirai, T., Hirose, S. J. Immunol. (2002)
- B lymphocyte memory: role of stromal cell complement and FcgammaRIIB receptors. Barrington, R.A., Pozdnyakova, O., Zafari, M.R., Benjamin, C.D., Carroll, M.C. J. Exp. Med. (2002)
- Fc gammaRII (CD32) is linked to apoptotic pathways in murine granulocyte precursors and mature eosinophils. de Andrés, B., Mueller, A.L., Blum, A., Weinstock, J., Verbeek, S., Sandor, M., Lynch, R.G. Blood (1997)
- Regulated expression and inhibitory function of Fcgamma RIIb in human monocytic cells. Tridandapani, S., Siefker, K., Teillaud, J.L., Carter, J.E., Wewers, M.D., Anderson, C.L. J. Biol. Chem. (2002)
- Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. Hamaguchi, Y., Xiu, Y., Komura, K., Nimmerjahn, F., Tedder, T.F. J. Exp. Med. (2006)
- Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap. Isnardi, I., Lesourne, R., Bruhns, P., Fridman, W.H., Cambier, J.C., Daëron, M. J. Biol. Chem. (2004)
- A critical role for Fc gamma RIIB in the induction of rheumatoid factors. Moll, T., Nitschke, L., Carroll, M., Ravetch, J.V., Izui, S. J. Immunol. (2004)
- Tumor necrosis factor induces a block in the cotranslation of Fc gamma RIIb mRNA in mouse peritoneal macrophages. Chicheportiche, Y., Vassalli, P. J. Biol. Chem. (1994)
- Expression of Fc gamma RIII defines distinct subpopulations of fetal liver B cell and myeloid precursors. Carlsson, L., Candéias, S., Staerz, U., Keller, G. Eur. J. Immunol. (1995)
- Molecular cloning and expression of the mouse high affinity Fc receptor for IgG. Sears, D.W., Osman, N., Tate, B., McKenzie, I.F., Hogarth, P.M. J. Immunol. (1990)
- Proteolysis induces increased binding affinity of the monocyte type II FcR for human IgG. van de Winkel, J.G., van Ommen, R., Huizinga, T.W., de Raad, M.A., Tuijnman, W.B., Groenen, P.J., Capel, P.J., Koene, R.A., Tax, W.J. J. Immunol. (1989)
- Dynamic interactions of Fc gamma receptor IIB with filamin-bound SHIP1 amplify filamentous actin-dependent negative regulation of Fc epsilon receptor I signaling. Lesourne, R., Fridman, W.H., Daëron, M. J. Immunol. (2005)
- Unique features of SHIP, SHP-1 and SHP-2 binding to FcgammaRIIb revealed by surface plasmon resonance analysis. Famiglietti, S.J., Nakamura, K., Cambier, J.C. Immunol. Lett. (1999)
- Two distinct regions of the mouse beta Fc gamma R gene control its transcription. Bonnerot, C., Choukroun, V., Marloie, M.A., Fridman, W.H. Immunobiology (1992)
- Coordinate expression of activating Fc gamma receptors I and III and inhibiting Fc gamma receptor type II in the determination of joint inflammation and cartilage destruction during immune complex-mediated arthritis. Nabbe, K.C., Blom, A.B., Holthuysen, A.E., Boross, P., Roth, J., Verbeek, S., van Lent, P.L., van den Berg, W.B. Arthritis Rheum. (2003)
- Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils. Hamada, F., Aoki, M., Akiyama, T., Toyoshima, K. Proc. Natl. Acad. Sci. U.S.A. (1993)
- IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP1, SHP-1, and Btk activity. Crow, A.R., Song, S., Freedman, J., Helgason, C.D., Humphries, R.K., Siminovitch, K.A., Lazarus, A.H. Blood (2003)
- The role of Fc-receptors in murine mercury-induced systemic autoimmunity. Martinsson, K., Hultman, P. Clin. Exp. Immunol. (2006)
- Role of SHIP in FcgammaRIIb-mediated inhibition of Ras activation in B cells. Tridandapani, S., Phee, H., Shivakumar, L., Kelley, T.W., Coggeshall, K.M. Mol. Immunol. (1998)
- Induction of intracellular Ca2+ mobilization and cytotoxicity by hybrid mouse monoclonal antibodies. Fc gamma RII regulation of Fc gamma RI-triggered functions or signaling? Koolwijk, P., Van de Winkel, J.G., Pfefferkorn, L.C., Jacobs, C.W., Otten, I., Spierenburg, G.T., Bast, B.J. J. Immunol. (1991)
- Src homology 2 domain-containing inositol 5-phosphatase 1 mediates cell cycle arrest by FcgammaRIIB. Malbec, O., Schmitt, C., Bruhns, P., Krystal, G., Fridman, W.H., Daëron, M. J. Biol. Chem. (2001)
- IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice. Wernersson, S., Karlsson, M.C., Dahlström, J., Mattsson, R., Verbeek, J.S., Heyman, B. J. Immunol. (1999)
- Fc gamma RIIB regulates nasal and oral tolerance: a role for dendritic cells. Samsom, J.N., van Berkel, L.A., van Helvoort, J.M., Unger, W.W., Jansen, W., Thepen, T., Mebius, R.E., Verbeek, S.S., Kraal, G. J. Immunol. (2005)
- A new set of monoclonal antibodies against human Fc gamma RII (CD32) and Fc gamma RIII (CD16): characterization and use in various assays. Vely, F., Gruel, N., Moncuit, J., Cochet, O., Rouard, H., Dare, S., Galon, J., Sautes, C., Fridman, W.H., Teillaud, J.L. Hybridoma (1997)
- Ontogeny and distribution of the murine B cell Fc gamma RII. Foy, T.M., Lynch, R.G., Waldschmidt, T.J. J. Immunol. (1992)
- Biochemical characterization of murine lymphoid alloantigen Ly-m20.2, a cell surface marker controlled by a gene linked to the Mls locus. Mark, W.H., Kimura, S., Hämmerling, U. J. Immunol. (1985)
- Differential expression of the inhibitory IgG Fc receptor FcgammaRIIB on germinal center cells: implications for selection of high-affinity B cells. Rao, S.P., Vora, K.A., Manser, T. J. Immunol. (2002)