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Gene Review

RHD1  -  UDP-glucose 4-epimerase

Arabidopsis thaliana

Synonyms: F15H21.11, F15H21_11, REB1, ROOT EPIDERMAL BULGER1, ROOT HAIR DEFECTIVE 1, ...
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High impact information on RHD1

  • We find that ethylene specifically suppresses all visible aspects of the rhd1 phenotype [1].
  • Ethylene restores the biosynthesis of galactose-containing xyloglucan and arabinosylated galactan cell wall polymers in rhd1 back to wild-type levels [1].
  • The RHD1 isoform is specifically required for the galactosylation of xyloglucan (XG) and type II arabinogalactan (AGII) but is not involved either in D-galactose detoxification or in galactolipid biosynthesis [2].
  • We show that REB1 is allelic to ROOT HAIR DEFICIENT 1 (RHD1), one of five ubiquitously expressed genes that encode isoforms of UDP-D-glucose 4-epimerase (UGE), an enzyme that acts in the formation of UDP-D-galactose (UDP-D-Gal) [2].
  • The REB1/RHD1 gene belongs to a family of UDP-D-Glucose 4-epimerases involved in the synthesis of D-Galactose (Gal) [3].

Biological context of RHD1


Associations of RHD1 with chemical compounds


  1. Growth regulators and the control of nucleotide sugar flux. Seifert, G.J., Barber, C., Wells, B., Roberts, K. Plant Cell (2004) [Pubmed]
  2. Galactose biosynthesis in Arabidopsis: genetic evidence for substrate channeling from UDP-D-galactose into cell wall polymers. Seifert, G.J., Barber, C., Wells, B., Dolan, L., Roberts, K. Curr. Biol. (2002) [Pubmed]
  3. The reb1-1 mutation of Arabidopsis. Effect on the structure and localization of galactose-containing cell wall polysaccharides. Nguema-Ona, E., Andème-Onzighi, C., Aboughe-Angone, S., Bardor, M., Ishii, T., Lerouge, P., Driouich, A. Plant Physiol. (2006) [Pubmed]
  4. Mutation of a UDP-glucose-4-epimerase alters nematode susceptibility and ethylene responses in Arabidopsis roots. Wubben, M.J., Rodermel, S.R., Baum, T.J. Plant J. (2004) [Pubmed]
  5. Susceptibility to the sugar beet cyst nematode is modulated by ethylene signal transduction in Arabidopsis thaliana. Wubben, M.J., Su, H., Rodermel, S.R., Baum, T.J. Mol. Plant Microbe Interact. (2001) [Pubmed]
  6. UDP-glucose 4-epimerase isoforms UGE2 and UGE4 cooperate in providing UDP-galactose for cell wall biosynthesis and growth of Arabidopsis thaliana. Rösti, J., Barton, C.J., Albrecht, S., Dupree, P., Pauly, M., Findlay, K., Roberts, K., Seifert, G.J. Plant. Cell (2007) [Pubmed]
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