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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

OTC  -  ornithine carbamoyltransferase

Arabidopsis thaliana

Synonyms: F1B16.13, F1B16_13, ORNITHINE CARBAMOYLTRANSFERASE
 
 
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High impact information on OTC

  • The OTC-AUL1 locus maps at the bottom of chromosome 1 [1].
  • Transcript mapping revealed that at least 22 bp within the OTC-AUL1 intercoding region are transcribed from both strands, which makes this one of the rarely described cases of convergent and overlapping transcription units in the nuclear genome of a multicellular eukaryote [1].
  • We report here the isolation of a T-DNA-tagged mutant displaying sensitivity to ornithine, whose characterization has allowed for the identification of several complementary and genomic DNA clones encoding the OTC and auxilin-like 1 (AUL1) proteins of the crucifer Arabidopsis thaliana [1].
  • The introns of C. lineata OCT gene are larger than those of A. thaliana, except for intron 3 [2].
  • The nucleotide sequences of the complete ornithine carbamoyltransferase (OCT) gene containing 3,964 bp 3' region and 1,701 bp promoter region were determined from Canavalia lineata leaves [2].
 

Biological context of OTC

References

  1. OTC and AUL1, two convergent and overlapping genes in the nuclear genome of Arabidopsis thaliana. Quesada, V., Ponce, M.R., Micol, J.L. FEBS Lett. (1999) [Pubmed]
  2. Genomic structure of ornithine carbamoyltransferase gene from Canavalia lineata. Lee, Y., Yoo, S.K., Lee, J.S., Kwon, Y.M. Mol. Cells (2000) [Pubmed]
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