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Gene Review

OTC  -  ornithine carbamoyltransferase

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Disease relevance of OTC


High impact information on OTC


Chemical compound and disease context of OTC


Biological context of OTC

  • In contrast, the OCT activities were fairly constant for each tissue as a function of gestational age [8].

Anatomical context of OTC


Associations of OTC with chemical compounds

  • Thus, environmental factors, e.g., ATP and carbamoyl phosphate, appear to influence OTC stability to proteases [5].
  • On the contrary, the apparent Km's of human liver OTC were 0.6 mM for ornithine and 0.12 mM for carbamyl phosphate [6].
  • Since the inactivation is prevented by leupeptin, antipain and L-(tosylamido-2-phenyl)ethylchloromethyl ketone, the proteolytic susceptibility of OTC to lysosomes could be due to thiol endopeptidase(s) [11].
  • The renal OTC clearance, the renal creatinine clearance, the urinary flow, and the interrelationships of these were determined on the basis of urine and plasma data [12].
  • Three groups of 10 calves each were treated with two, three or four doses of 20 mg kg-1 long-acting oxytetracycline (OTC/LA) at six- to seven-day intervals starting from day 6 after vaccination [9].

Other interactions of OTC

  • Liver biopsies were obtained on d -28, -14, 1, 28, and 56 relative to calving, and the abundances of AS, OTC, PC, PEPCK, and 18S mRNA were determined by Northern blot analysis of total RNA [13].
  • The enzymes measured were: carbamyl phosphate synthetase (CPS), ornithine transcarbamylase (OTC), argininosuccinate synthetase (AS), argininosuccinase (AL) and arginase (A) [14].

Analytical, diagnostic and therapeutic context of OTC


  1. Use of oxytetracycline and tylosin in intensive calf farming: evaluation of transfer to manure and soil. De Liguoro, M., Cibin, V., Capolongo, F., Halling-Sørensen, B., Montesissa, C. Chemosphere (2003) [Pubmed]
  2. The effect of oxytetracycline treatment on immunity induced by Anaplasma centrale. Pipano, E., Krigel, Y., Markovics, A., Shkap, V. Vet. Microbiol. (1992) [Pubmed]
  3. The essential sulfhydryl group of ornithine transcarbamylases. pH dependence of the spectra of its 2-mercuri-4-nitrophenol derivative. Marshall, M., Cohen, P.P. J. Biol. Chem. (1980) [Pubmed]
  4. Ornithine transcarbamylases. Ordering of S-cyano peptides and location of characteristically reactive cysteinyl residues within the sequence. Marshall, M., Cohen, P.P. J. Biol. Chem. (1980) [Pubmed]
  5. ATP and other purine nucleotides stimulate the inactivation of ornithine transcarbamylase by broken lysosomes. Navarro, A., Grisolía, S. FEBS Lett. (1984) [Pubmed]
  6. Ornithine transcarbamylase (OTC) in white blood cells. Nagata, N., Akaboshi, I., Yamamoto, J., Matsuda, I., Ohtsuka, H., Katsuki, T. Pediatr. Res. (1980) [Pubmed]
  7. Fatty infiltration of liver in spontaneously ketotic dairy cows. Gröhn, Y., Lindberg, L.A., Bruss, M.L., Farver, T.B. J. Dairy Sci. (1983) [Pubmed]
  8. Developmental changes of tissue enzyme patterns in the bovine fetus with gestational age. Baetz, A.L., Hubbert, W.T., Graham, C.K. Biol. Neonate (1975) [Pubmed]
  9. Use of long-acting oxytetracycline in the immunisation of cattle against Babesia bovis and B bigemina. Pipano, E., Markovics, A., Kriegel, Y., Frank, M., Fish, L. Res. Vet. Sci. (1987) [Pubmed]
  10. A sensitive enzyme-linked immunosorbent assay of serum ornithine carbamoyltransferase. Watanabe, Y., Mori, S., Ozaki, M., Fujiyama, S., Sato, T., Mori, M. Enzyme Protein (1994) [Pubmed]
  11. Purine nucleotides stimulate while carbamoyl phosphate protects inactivation of ornithine transcarbamoylase by disrupted lysosomes. Navarro, A., Grisolía, S. Eur. J. Biochem. (1985) [Pubmed]
  12. Pharmacokinetics and renal clearance of oxytetracycline after intravenous and intramuscular administration to dairy cows. Nouws, J.F., Vree, T.B., Termond, E., Lohuis, J., van Lith, P., Binkhorst, G.J., Breukink, H.J. The Veterinary quarterly. (1985) [Pubmed]
  13. Rumen undegradable protein, rumen-protected choline and mRNA expression for enzymes in gluconeogenesis and ureagenesis in periparturient dairy cows. Hartwell, J.R., Cecava, M.J., Donkin, S.S. J. Dairy Sci. (2001) [Pubmed]
  14. Effect of age on activities of urea cycle enzymes in the bovine. Boling, J.A., Nuzum, C.T. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1975) [Pubmed]
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