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Gene Review

Il6st  -  interleukin 6 signal transducer

Rattus norvegicus

Synonyms: Ac1055, Gp130, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, ...
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Disease relevance of Il6st


High impact information on Il6st


Biological context of Il6st

  • These data indicate that ligands activating the gp130 pathway have the ability to profoundly alter neuronal cell shape and polarity by selectively causing the retraction of dendrites [10].
  • When both forms of gp130 are deglycosylated the resulting core peptides migrate to identical positions in a denatured protein gel, indicating that the principal difference between the two forms resides in the extent of their glycosylation [11].
  • The kinetics of gp130 maturation and surface expression were determined [11].
  • Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes [12].
  • The nucleotide sequence of gp130 from a human B-cell line has been reported [13].

Anatomical context of Il6st

  • We speculate that gp130 cytokines play a paracrine, neuromodulatory role in the hippocampus since both before and after seizure, principal cells appear to be the major cell type expressing the receptors for these cytokines [3].
  • A progressive and chronic induction of gp130 was observed in cells that appeared to be associated with blood vessels [3].
  • Blockade of LIFRbeta inhibited the sweat gland differentiation activity in neuron/gland co-cultures, and extracts of gland-containing footpads stimulated tyrosine phosphorylation of LIFRbeta and gp130 [14].
  • We conclude that, by interacting with membrane gp130 and possibly by activating Janus kinase/STAT pathways, IL6RIL6 chimera induces OPCs to differentiate into mature oligodendrocytes, promotes their survival, and could deserve investigation as a therapeutic strategy for enhancing remyelination [15].
  • Ribonuclease protection analyses demonstrated the presence of gp130 mRNA in four different nontransformed cell types: hepatocytes, astrocytes, fibroblasts, and endothelial cells [13].

Associations of Il6st with chemical compounds

  • Positions 268 and 269 of CNTFRalpha appear to be critical for its interaction with gp130 and LIFRbeta, whereby alanine substitution of the residues at these positions results in antagonism of the CNTF-induced response [1].
  • This interaction leads to the association and activation of a second membrane glycoprotein, gp130, which is the IL-6 signal transducing molecule [13].
  • The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons [16].
  • Dexamethasone increases receptor mRNA levels 2.7-fold above controls but has no detectable effect on that of gp130 [17].
  • Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta [18].

Physical interactions of Il6st

  • CONCLUSIONS: Array analysis revealed changes in mRNA levels of several genes not previously associated with activation of the gp130/LIF receptor complex [19].

Regulatory relationships of Il6st


Other interactions of Il6st

  • Leukemia inhibitory factor receptor and gp130 were expressed in neurons, and the ischemic damage of these proteins was rescued in the high-LIF group [2].
  • By contrast, the mRNA and protein levels for CT-1 and the mRNA level for gp130 did not vary in these two models [23].
  • A supershift was observed with anti-C/EBP-beta but not with anti-alpha or anti-delta antibodies. mRNA and protein levels of IL-6 and gp130 were detected at low levels in controls, increased at 1 hour of reperfusion, and remained high until 6 hours of reperfusion [9].
  • Like primary decidual cells in culture, GG-AD cells express IL-6, IL-6R, and gp130 mRNA [24].
  • Thus, GATA-5 may be involved in gp130 signaling in cardiac myocytes [25].

Analytical, diagnostic and therapeutic context of Il6st

  • Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis showed that IL-11 and its receptor, CNTF and its receptor, LIFR, and gp130 were constitutively expressed throughout the culture period [26].
  • Immunoprecipitation and metabolic labeling experiments demonstrate, in addition to a mature surface expressed gp130, the presence of a major immature form of the molecule within the cell [11].
  • We report here the cloning and sequence analysis of the gp130 molecule derived from rat liver [13].
  • Molecular cloning and characterization of the rat liver IL-6 signal transducing molecule, gp130 [13].
  • The expression of glycoprotein 130 (gp130) was studied in rat primary Sertoli cells by Northern blot analysis [27].


  1. Alanine substitution for Thr268 and Asp269 of soluble ciliary neurotrophic factor (CNTF) receptor alpha component defines a specific antagonist for the CNTF response. Auguste, P., Robledo, O., Olivier, C., Froger, J., Praloran, V., Pouplard-Barthelaix, A., Gascan, H. J. Biol. Chem. (1996) [Pubmed]
  2. Activation of cytokine signaling through leukemia inhibitory factor receptor (LIFR)/gp130 attenuates ischemic brain injury in rats. Suzuki, S., Yamashita, T., Tanaka, K., Hattori, H., Sawamoto, K., Okano, H., Suzuki, N. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  3. Spatiotemporal distribution of gp130 cytokines and their receptors after status epilepticus: comparison with neuronal degeneration and microglial activation. Rosell, D.R., Nacher, J., Akama, K.T., McEwen, B.S. Neuroscience (2003) [Pubmed]
  4. Gene expression of receptors for IL-6, LIF, and CNTF in regenerating skeletal muscles. Kami, K., Morikawa, Y., Sekimoto, M., Senba, E. J. Histochem. Cytochem. (2000) [Pubmed]
  5. Allelic imbalance and altered expression of genes in chromosome 2q11-2q16 from rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Qiu, C., Yu, M., Shan, L., Snyderwine, E.G. Oncogene (2003) [Pubmed]
  6. The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures. Romas, E., Udagawa, N., Zhou, H., Tamura, T., Saito, M., Taga, T., Hilton, D.J., Suda, T., Ng, K.W., Martin, T.J. J. Exp. Med. (1996) [Pubmed]
  7. Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6. Ihara, S., Nakajima, K., Fukada, T., Hibi, M., Nagata, S., Hirano, T., Fukui, Y. EMBO J. (1997) [Pubmed]
  8. gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. Janoschek, R., Plum, L., Koch, L., Münzberg, H., Diano, S., Shanabrough, M., Müller, W., Horvath, T.L., Brüning, J.C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. Regulation of CCAAT/Enhancer binding protein, interleukin-6, interleukin-6 receptor, and gp130 expression during myocardial ischemia/reperfusion. Chandrasekar, B., Mitchell, D.H., Colston, J.T., Freeman, G.L. Circulation (1999) [Pubmed]
  10. Leukemia inhibitory factor and ciliary neurotrophic factor cause dendritic retraction in cultured rat sympathetic neurons. Guo, X., Chandrasekaran, V., Lein, P., Kaplan, P.L., Higgins, D. J. Neurosci. (1999) [Pubmed]
  11. Biosynthetic and glycosylation events of the IL-6 receptor beta-subunit, gp130. Wang, Y., Fuller, G.M. J. Cell. Biochem. (1995) [Pubmed]
  12. Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes. Fujio, Y., Matsuda, T., Oshima, Y., Maeda, M., Mohri, T., Ito, T., Takatani, T., Hirata, M., Nakaoka, Y., Kimura, R., Kishimoto, T., Azuma, J. FEBS Lett. (2004) [Pubmed]
  13. Molecular cloning and characterization of the rat liver IL-6 signal transducing molecule, gp130. Wang, Y., Nesbitt, J.E., Fuentes, N.L., Fuller, G.M. Genomics (1992) [Pubmed]
  14. A sweat gland-derived differentiation activity acts through known cytokine signaling pathways. Habecker, B.A., Symes, A.J., Stahl, N., Francis, N.J., Economides, A., Fink, J.S., Yancopoulos, G.D., Landis, S.C. J. Biol. Chem. (1997) [Pubmed]
  15. Soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro differentiation of purified rat oligodendroglial lineage cells. Valerio, A., Ferrario, M., Dreano, M., Garotta, G., Spano, P., Pizzi, M. Mol. Cell. Neurosci. (2002) [Pubmed]
  16. The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons. Sun, Y., März, P., Otten, U., Ge, J., Rose-John, S. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  17. Differential regulation of interleukin-6 receptor and gp130 gene expression in rat hepatocytes. Nesbitt, J.E., Fuller, G.M. Mol. Biol. Cell (1992) [Pubmed]
  18. Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta. Vallières, L., Rivest, S. J. Neurochem. (1997) [Pubmed]
  19. Leukaemia inhibitory factor alters expression of genes involved in rat cardiomyocyte energy metabolism. Florholmen, G., Andersson, K.B., Yndestad, A., Austbø, B., Henriksen, U.L., Christensen, G. Acta Physiol. Scand. (2004) [Pubmed]
  20. Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes. Kunisada, K., Hirota, H., Fujio, Y., Matsui, H., Tani, Y., Yamauchi-Takihara, K., Kishimoto, T. Circulation (1996) [Pubmed]
  21. Autocrine/Paracrine secretion of IL-6 family cytokines causes angiotensin II-induced delayed STAT3 activation. Sano, M., Fukuda, K., Kodama, H., Takahashi, T., Kato, T., Hakuno, D., Sato, T., Manabe, T., Tahara, S., Ogawa, S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  22. Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes. Takahashi, N., Saito, Y., Kuwahara, K., Harada, M., Tanimoto, K., Nakagawa, Y., Kawakami, R., Nakanishi, M., Yasuno, S., Usami, S., Yoshimura, A., Nakao, K. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  23. Increased expression of IL-6 and LIF in the hypertrophied left ventricle of TGR(mRen2)27 and SHR rats. Kurdi, M., Randon, J., Cerutti, C., Bricca, G. Mol. Cell. Biochem. (2005) [Pubmed]
  24. The expression of interleukin-6 (IL-6), IL-6 receptor, and gp130-kilodalton glycoprotein in the rat decidua and a decidual cell line: regulation by 17beta-estradiol and prolactin. Deb, S., Tessier, C., Prigent-Tessier, A., Barkai, U., Ferguson-Gottschall, S., Srivastava, R.K., Faliszek, J., Gibori, G. Endocrinology (1999) [Pubmed]
  25. GATA-5 is involved in leukemia inhibitory factor-responsive transcription of the beta-myosin heavy chain gene in cardiac myocytes. Morimoto, T., Hasegawa, K., Kaburagi, S., Kakita, T., Masutani, H., Kitsis, R.N., Matsumori, A., Sasayama, S. J. Biol. Chem. (1999) [Pubmed]
  26. Expression of leukemia inhibitory factor (LIF)/interleukin-6 family cytokines and receptors during in vitro osteogenesis: differential regulation by dexamethasone and LIF. Liu, F., Aubin, J.E., Malaval, L. Bone (2002) [Pubmed]
  27. Expression and regulation of gp130 messenger ribonucleic acid in cultured immature rat Sertoli cells. Fujisawa, M., Okuda, Y., Fujioka, H., Kamidono, S. Endocr. Res. (2002) [Pubmed]
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