The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SLC9A7  -  solute carrier family 9, subfamily A (NHE7...

Homo sapiens

Synonyms: NHE-7, NHE7, Na(+)/H(+) exchanger 7, SLC9A6, Sodium/hydrogen exchanger 7, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SLC9A7

  • Thus, NHE7 displays unique functional and pharmacological properties and may play an important role in maintaining cation homeostasis of this important organelle [1].
  • Here, we describe the cloning of a novel gene (NHE7) in humans that is homologous to Na+/H+ exchangers, is ubiquitously expressed, and localizes predominantly to the trans-Golgi network [1].
  • The activity of NHE7 was also found to be relatively insensitive to inhibition by amiloride but could be antagonized by the analogue benzamil and the unrelated compound quinine [1].
  • Conversely, a GFP-tagged TM2-TM3 construct of SCAMP2 interacted with NHE7, but also led to the redistribution of NHE7 to dispersed vesicular structures [2].
  • Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7 [2].

Biological context of SLC9A7

  • To gain insight into these processes, yeast two-hybrid methodology was used to screen a human brain cDNA library for proteins that interact with the cytoplasmic C-terminus of NHE7 [2].
  • Endocytosis of NHE7 was efficiently inhibited by pharmacological maneuvers that block clathrin-dependent endocytosis, whereas dominant-negative caveolin mutants or methyl beta-cyclodextrin did not affect NHE7-internalization [3].

Anatomical context of SLC9A7

  • Thus, NHE7 associates with both caveolae/lipid rafts and non-caveolae/lipid raft, and the two pools likely exhibit separate dynamics [3].
  • NHE7 was identified as the first mammalian organelle-membrane type (Na(+), K(+))/H(+) exchanger that may contribute to the ion homeostasis in the trans-Golgi network (TGN) and endosomes [3].

Associations of SLC9A7 with chemical compounds

  • NHE7 is partly associated with caveolae/lipid raft fractions, and heterologous expression of caveolin dominant-negative mutants as well as cholesterol depriving drugs diminished such associations [3].

Physical interactions of SLC9A7

  • Biochemical analyses indicated that the C-terminal cytoplasmic tail of NHE7 bound preferentially to a highly conserved cytoplasmic loop between the second and the third transmembrane segments (TM2-TM3 loop) of SCAMP2 [2].

Other interactions of SLC9A7

  • The majority of the NHE7-SCAMP complexes accumulated at the TGN, but a minor fraction also resided in recycling vesicles [2].
  • All, except NHE-6 and NHE-7, which are located intracellularly, are restricted to the sarcolemmal membrane [4].


  1. Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network. Numata, M., Orlowski, J. J. Biol. Chem. (2001) [Pubmed]
  2. Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7. Lin, P.J., Williams, W.P., Luu, Y., Molday, R.S., Orlowski, J., Numata, M. J. Cell. Sci. (2005) [Pubmed]
  3. Caveolins bind to (Na(+), K(+))/H(+) exchanger NHE7 by a novel binding module. Lin, P.J., Williams, W.P., Kobiljski, J., Numata, M. Cell. Signal. (2007) [Pubmed]
  4. NHE-1 inhibition: from protection during acute ischaemia/reperfusion to prevention/reversal of myocardial remodelling. Linz, W.J., Busch, A.E. Naunyn Schmiedebergs Arch. Pharmacol. (2003) [Pubmed]
WikiGenes - Universities