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Gene Review

BPH1  -  Bph1p

Saccharomyces cerevisiae S288c

Synonyms: Beige protein homolog 1, YCR032W, YCR32W, YCR591, YCR601
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High impact information on BPH1

  • Neither disruption nor overexpression of BPH1 affected vacuole morphology as assessed by fluorescence microscopy [1].
  • Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting [1].
  • YCR601 was disrupted by internal deletion and insertion of LEU2 gene and is a non-essential gene, however, it is transcribed during vegetative growth yielding a polyadenylated mRNA of approximately 7 kb [2].
  • The segment contains two long open reading frames (ORFs): YCR591 which starts in the adjacent fragment H9G (situated towards CRY1 and the centromere), and continues with 1833 codons in YCR59 [3].
  • Excellent agreement in both location and length is found between the ORFs YCR591 and YCR592 and the transcripts 86 and 87 respectively in the Yoshikawa and Isono (1990) map of chromosome III [3].

Biological context of BPH1

  • Together, these data suggest that Bph1p associates with a membrane and is involved in protein sorting and cell wall formation [1].
  • This sequence contains an unusual long open reading frame, YCR601, of 6501 bp that encodes for a protein of 2167 amino acids that show no homology with other known proteins [2].
  • The sequence of 8.8 kb of yeast chromosome III cloned in lambda PM3270 contains an unusual long ORF (YCR601) [2].


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