The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SFI1  -  Sfi1p

Saccharomyces cerevisiae S288c

Synonyms: L1373, Protein SFI1, Suppressor of fermentation induced loss of stress resistance protein 1, YLL003W
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SFI1

  • The Saccharomyces cerevisiae centrin, Cdc31p, binds Sfi1p on multiple conserved repeats; both proteins localize to the SPB half-bridge, where the new SPB is assembled [1].
  • The discovery of Sfi1p as a novel binding partner for the Ca2+-binding protein centrin has provided new insight into the dynamic behavior of centrosomes [2].
  • We have called it SFI1, for suppressor of fil1 [3].
  • SFI1 is an essential gene [3].
  • Cells expressing SFI1 under the control of a galactose-inducible promoter arrest after addition of glucose as doublets of undivided mother and daughter cells [3].

Biological context of SFI1

  • Hence, Sfi1 might be required for correct mitotic spindle assembly and its precise role might be in chromosome condensation [3].
  • Further analysis showed that Sfi1 is required for cell cycle progression, more specifically for progression through G(2)-M transition [3].
  • The restriction endonucleases Sma1 and Sfi1 which recognise rare-medium frequency sites in the Arabidopsis genome were used [4].

Anatomical context of SFI1

  • We identified a novel functional relationship in SPB separation between the microtubule stabilizing protein Bik1p/CLIP-170 and the SPB half-bridge protein Sfi1p [5].

Analytical, diagnostic and therapeutic context of SFI1

  • Electron microscopy (EM) shadowing of an Sfi1p-centrin complex with 15 Sfi1 repeats and 15 centrins bound showed filaments 60 nm long, compatible with all the Sfi1 repeats as a continuous alpha helix [1].


  1. Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication. Li, S., Sandercock, A.M., Conduit, P., Robinson, C.V., Williams, R.L., Kilmartin, J.V. J. Cell Biol. (2006) [Pubmed]
  2. Centrosomes: Sfi1p and centrin unravel a structural riddle. Salisbury, J.L. Curr. Biol. (2004) [Pubmed]
  3. Deletion of SFI1, a novel suppressor of partial Ras-cAMP pathway deficiency in the yeast Saccharomyces cerevisiae, causes G(2) arrest. Ma, P., Winderickx, J., Nauwelaers, D., Dumortier, F., De Doncker, A., Thevelein, J.M., Van Dijck, P. Yeast (1999) [Pubmed]
  4. Arabidopsis YAC restriction mapping. Morroll, S.M., Wilson, Z.A. Genome (1998) [Pubmed]
  5. Deletion of RNQ1 gene reveals novel functional relationship between divergently transcribed Bik1p/CLIP-170 and Sfi1p in spindle pole body separation. Strawn, L.A., True, H.L. Curr. Genet. (2006) [Pubmed]
WikiGenes - Universities