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Gene Review

ADE13  -  adenylosuccinase ADE13

Saccharomyces cerevisiae S288c

Synonyms: ASL, ASase, Adenylosuccinase, Adenylosuccinate lyase, BRA1, ...
 
 
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Disease relevance of ADE13

  • Circular dichroism spectra and predictive software suggested that peptide tF2 (S1ISPW5GFSGL10 LRWSY15), selected from a phage display library to bind the modified anticodon domain of yeast tRNAPhe (ASL), adopted a beta-sheet structure [1].
 

High impact information on ADE13

 

Biological context of ADE13

  • These results were unexpected, since ARG57 had been localized to chromosome 7, while a mutation causing an ASL deficiency had been linked to ade1, which is on chromosome R [6].

References

  1. Sequence-altered peptide adopts optimum conformation for modification-dependent binding of the yeast tRNAPhe anticodon domain. Mucha, P., Szyk, A., Rekowski, P., Agris, P.F. Protein J. (2004) [Pubmed]
  2. Role of the myb-like protein bas1p in Saccharomyces cerevisiae: a proteome analysis. Denis, V., Boucherie, H., Monribot, C., Daignan-Fornier, B. Mol. Microbiol. (1998) [Pubmed]
  3. The isolation and characterization of Saccharomyces cerevisiae mutants that constitutively express purine biosynthetic genes. Guetsova, M.L., Lecoq, K., Daignan-Fornier, B. Genetics (1997) [Pubmed]
  4. Inhibition of adenylosuccinase by adenylophosphonopropionate and related compounds. Brand, L.M., Lowenstein, J.M. Biochemistry (1978) [Pubmed]
  5. BIP, a BRAM-interacting protein involved in TGF-beta signalling, regulates body length in Caenorhabditis elegans. Sugawara, K., Morita, K., Ueno, N., Shibuya, H. Genes Cells (2001) [Pubmed]
  6. The ARG4 gene of Candida albicans. Hoyer, L.L., Magee, B.B., Rikkerink, E.H., Scherer, S. Gene (1994) [Pubmed]
 
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