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Gene Review

ADSL  -  adenylosuccinate lyase

Gallus gallus

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Disease relevance of ADSL


High impact information on ADSL

  • When rats are starved, the rate of de novo synthesis of adenine mononucleotide decreases in spleen and liver but not in kidney, suggesting a regulatory role for adenylosuccinase in purine biosynthesis [2].
  • Adenylosuccinase activity of rat liver is depressed by prolonged starvation, cortisol administration, high protein diets, and alloxan diabetes [2].
  • The recovery of adenylosuccinase activity is equally rapid after refeeding a balanced diet, or corn oil, or glucose, and is not inhibited by injection of glucagon, in contrast to malic enzyme activity [2].
  • The low activity of adenylosuccinase in liver of severely starved rats is inconsistent with the proposal (Moss, K. M., and McGivan, J.D. (1975) Biochem. J. 150, 275-283) that the purine nucleotide cycle plays a major role in ammonia production for urea synthesis, at least under these conditions [2].
  • Transfectant L cell lines expressing delta 2 exhibited significantly higher ASL activity than those without [3].

Biological context of ADSL

  • To test this possibility, we cloned the delta 2 gene on a plasmid, introduced it into mouse cells, and assessed expression and ASL activity in comparison with delta 1 [3].
  • Close similarity of the delta 2 gene to mammalian argininosuccinate lyase (ASL)-encoding genes in organization and deduced amino acid sequence of the encoded protein suggested that this gene may encode chicken ASL [3].
  • The 4.6 kbp intergenic spacer in the duck locus is 79% identical to the 4 kbp chicken spacer, except for the existence of a 615 bp CR1 element, highly reiterated in the duck genome, 1.8 kbp upstream of the duck ASL/delta 2 gene [4].

Associations of ADSL with chemical compounds

  • In conclusion, ADL, CYP450, ovoinhibitor, and PGDS represent the novel targets of estrogen, which regulates the transcriptional activity of these genes [5].
  • Four cDNA fragments that displayed dramatic change after estrogen administration were identified as liver adenylosuccinate lyase (ADL), phenobarbital-inducible cytochrome P-450 (CYP450), ovoinhibitor, and glutathione-dependent prostaglandin D2 synthase (PGDS) [5].


  1. Cloning of a cDNA encoding adenylosuccinate lyase by functional complementation in Escherichia coli. Aimi, J., Badylak, J., Williams, J., Chen, Z.D., Zalkin, H., Dixon, J.E. J. Biol. Chem. (1990) [Pubmed]
  2. Effect of diet on adenylosuccinase activity in various organs of rat and chicken. Brand, L.M., Lowenstein, J.M. J. Biol. Chem. (1978) [Pubmed]
  3. Expression of the chicken 'delta 2-crystallin' gene in mouse cells: evidence for encoding of argininosuccinate lyase. Kondoh, H., Araki, I., Yasuda, K., Matsubasa, T., Mori, M. Gene (1991) [Pubmed]
  4. Linkage and expression of the argininosuccinate lyase/delta-crystallin genes of the duck: insertion of a CR1 element in the intergenic spacer. Li, X., Wistow, G.J., Piatigorsky, J. Biochim. Biophys. Acta (1995) [Pubmed]
  5. Identification of estrogen-responsive genes in chick liver. Zhu, Y., Wang, M., Lin, H., Li, Z., Luo, J. Cell Tissue Res. (2001) [Pubmed]
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