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Gene Review

CST9  -  SUMO ligase CST9

Saccharomyces cerevisiae S288c

Synonyms: Chromosome stability protein 9, Molecular zipper protein 3, YLR394W, ZIP3
 
 
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High impact information on CST9

 

Biological context of CST9

  • Zip2 and Zip3 are previously characterized components of the synapsis initiation complex [4].
  • Crossing-over is decreased in the zip4 mutant (as in zip1, zip2, and zip3); the remaining crossovers are largely dependent on a parallel pathway utilizing Mms4. zip4 displays a novel phenotype: negative crossover interference, meaning that crossovers tend to cluster [4].
  • Zip3 provides a link between recombination enzymes and synaptonemal complex proteins [2].
  • The Zip3 protein colocalizes with Zip2 at discrete foci on meiotic chromosomes, corresponding to the sites where synapsis initiates [2].
  • The quantitative relationship between Zip3 foci, SC formation, and crossing over strongly implicates crossover-designated recombination intermediates as the sites of SC initiation [5].
 

Other interactions of CST9

  • Zip3 is shown to contain a RING finger whose structural features most closely match those of known ubiquitin E3s [6].

References

 
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