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Gene Review

PTA1  -  Pta1p

Saccharomyces cerevisiae S288c

Synonyms: FUN39, Pre-tRNA-processing protein PTA1, YAL043C
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High impact information on PTA1

  • Physical interactions of Ssu72 and Sub1 with Pta1 are mutually exclusive [1].
  • Here, we report that depletion of Glc7 causes shortened poly(A) tails in vivo and accumulation of phosphorylated Pta1, a CPF subunit [2].
  • Interestingly, levels of the polyadenylation factor Pta1 are also reduced in kin28 mutants, while several other polyadenylation factors remain stable [3].
  • Extracts prepared from pta1 mutant strains are impaired in the cleavage and the poly(A) addition of both GAL7 and CYC1 substrates and exhibit little processing activity even after prolonged incubation [4].
  • PTA1 has been mapped to the left arm of chromosome I near CDC24; the gene was sequenced and could encode a protein of 785 amino acids with a molecular weight of 88,417 [5].

Biological context of PTA1


Other interactions of PTA1

  • Six known components of the yeast (CPF) complex, together with Glc7p, were identified among the Pta1p-associated polypeptides using peptide mass fingerprint analysis [7].
  • Ref2 and Pta1 similarly affect at least one snoRNA transcript [8].


  1. Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1. He, X., Khan, A.U., Cheng, H., Pappas, D.L., Hampsey, M., Moore, C.L. Genes Dev. (2003) [Pubmed]
  2. Regulation of yeast mRNA 3' end processing by phosphorylation. He, X., Moore, C. Mol. Cell (2005) [Pubmed]
  3. Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II. Rodriguez, C.R., Cho, E.J., Keogh, M.C., Moore, C.L., Greenleaf, A.L., Buratowski, S. Mol. Cell. Biol. (2000) [Pubmed]
  4. Pta1, a component of yeast CF II, is required for both cleavage and poly(A) addition of mRNA precursor. Zhao, J., Kessler, M., Helmling, S., O'Connor, J.P., Moore, C. Mol. Cell. Biol. (1999) [Pubmed]
  5. PTA1, an essential gene of Saccharomyces cerevisiae affecting pre-tRNA processing. O'Connor, J.P., Peebles, C.L. Mol. Cell. Biol. (1992) [Pubmed]
  6. A novel heptameric sequence (TTAGTAA) is the binding site for a protein required for high level expression of pcbAB, the first gene of the penicillin biosynthesis in Penicillium chrysogenum. Kosalková, K., Marcos, A.T., Fierro, F., Hernando-Rico, V., Gutiérrez, S., Martín, J.F. J. Biol. Chem. (2000) [Pubmed]
  7. Novel interactions of Saccharomyces cerevisiae type 1 protein phosphatase identified by single-step affinity purification and mass spectrometry. Walsh, E.P., Lamont, D.J., Beattie, K.A., Stark, M.J. Biochemistry (2002) [Pubmed]
  8. Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. Nedea, E., He, X., Kim, M., Pootoolal, J., Zhong, G., Canadien, V., Hughes, T., Buratowski, S., Moore, C.L., Greenblatt, J. J. Biol. Chem. (2003) [Pubmed]
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