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Gene Review

RGT2  -  Rgt2p

Saccharomyces cerevisiae S288c

Synonyms: D2160, High-affinity glucose transporter RGT2, YDL138W
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High impact information on RGT2

  • Recent studies of Saccharomyces cerevisiae revealed sensors that detect extracellular amino acids (Ssy1p) or glucose (Snf3p and Rgt2p) and are evolutionarily related to the transporters of these nutrients [1].
  • Glucose sensing and signaling in Saccharomyces cerevisiae through the Rgt2 glucose sensor and casein kinase I [2].
  • A two-hybrid screen for Std1-interacting proteins identified the hydrophilic C-terminal domains of the glucose sensors, Snf3 and Rgt2 [3].
  • Rgt2p, a glucose transporter that functions as a high-glucose sensor, is required for conversion of Rgt1p into an activator by high levels of glucose [4].
  • RGT2 and GRR1 also play a role in regulating the expression of the HXT genes, which appear to be the upstream components of the glucose-transport-dependent pathway regulating maltose permease inactivation [5].

Biological context of RGT2


Anatomical context of RGT2

  • Snf3 and Rgt2 are integral plasma membrane proteins with unique carboxy-terminal domains that are predicted to be localized in the cytoplasm [9].

Associations of RGT2 with chemical compounds

  • We identified a dominant mutation in RGT2 that causes constitutive expression of several HXT genes, even in the absence of the inducer glucose [10].
  • Pathway 1 uses Rgt2p as a sensor of extracellular glucose and causes degradation of maltose permease protein [11].

Physical interactions of RGT2

  • Kinetic analysis of glucose uptake showed that the rgt1 and RGT2 suppressors restore glucose-repressible high-affinity glucose transport in a snf3 mutant [7].

Other interactions of RGT2

  • Rgt2p, which along with Snf3p monitors extracellular glucose levels, appears to be the glucose sensor for the glucose-transport-independent pathway [5].
  • The mutant forms block the transduction of the Snf3- and Rgt2-mediated glucose signals upstream of the Rgt1 transcriptional regulator [12].
  • This N-terminal PEST-like sequence is the target of both the Rgt2p-dependent and the Glc7p-Reg1p-dependent glucose signaling pathways [13].
  • Strikingly, the transmembrane components of several of these sensors, Ssylp, Mep2p, Snf3p. and Rgt2p, are unique members of nutrient-transport protein families [14].


  1. Competitive intra- and extracellular nutrient sensing by the transporter homologue Ssy1p. Wu, B., Ottow, K., Poulsen, P., Gaber, R.F., Albers, E., Kielland-Brandt, M.C. J. Cell Biol. (2006) [Pubmed]
  2. Glucose sensing and signaling in Saccharomyces cerevisiae through the Rgt2 glucose sensor and casein kinase I. Moriya, H., Johnston, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Std1 and Mth1 proteins interact with the glucose sensors to control glucose-regulated gene expression in Saccharomyces cerevisiae. Schmidt, M.C., McCartney, R.R., Zhang, X., Tillman, T.S., Solimeo, H., Wölfl, S., Almonte, C., Watkins, S.C. Mol. Cell. Biol. (1999) [Pubmed]
  4. Rgt1p of Saccharomyces cerevisiae, a key regulator of glucose-induced genes, is both an activator and a repressor of transcription. Ozcan, S., Leong, T., Johnston, M. Mol. Cell. Biol. (1996) [Pubmed]
  5. Two glucose sensing/signaling pathways stimulate glucose-induced inactivation of maltose permease in Saccharomyces. Jiang, H., Medintz, I., Michels, C.A. Mol. Biol. Cell (1997) [Pubmed]
  6. Identification of a calcineurin-independent pathway required for sodium ion stress response in Saccharomyces cerevisiae. Ganster, R.W., McCartney, R.R., Schmidt, M.C. Genetics (1998) [Pubmed]
  7. Dominant and recessive suppressors that restore glucose transport in a yeast snf3 mutant. Marshall-Carlson, L., Neigeborn, L., Coons, D., Bisson, L., Carlson, M. Genetics (1991) [Pubmed]
  8. Differential post-transcriptional regulation of yeast mRNAs in response to high and low glucose concentrations. Yin, Z., Hatton, L., Brown, A.J. Mol. Microbiol. (2000) [Pubmed]
  9. How do yeast cells sense glucose? Kruckeberg, A.L., Walsh, M.C., Van Dam, K. Bioessays (1998) [Pubmed]
  10. Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression. Ozcan, S., Dover, J., Rosenwald, A.G., Wölfl, S., Johnston, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  11. Metabolic signals trigger glucose-induced inactivation of maltose permease in Saccharomyces. Jiang, H., Medintz, I., Zhang, B., Michels, C.A. J. Bacteriol. (2000) [Pubmed]
  12. The HTR1 gene is a dominant negative mutant allele of MTH1 and blocks Snf3- and Rgt2-dependent glucose signaling in yeast. Schulte, F., Wieczorke, R., Hollenberg, C.P., Boles, E. J. Bacteriol. (2000) [Pubmed]
  13. A PEST-like sequence in the N-terminal cytoplasmic domain of Saccharomyces maltose permease is required for glucose-induced proteolysis and rapid inactivation of transport activity. Medintz, I., Wang, X., Hradek, T., Michels, C.A. Biochemistry (2000) [Pubmed]
  14. Sensors of extracellular nutrients in Saccharomyces cerevisiae. Forsberg, H., Ljungdahl, P.O. Curr. Genet. (2001) [Pubmed]
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