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Gene Review

POL12  -  DNA-directed DNA polymerase alpha subunit...

Saccharomyces cerevisiae S288c

Synonyms: DNA polymerase I subunit B, DNA polymerase alpha subunit B, DNA polymerase alpha:primase complex p86 subunit, DNA polymerase-primase complex p74 subunit, Pol alpha-primase complex p86 subunit, ...
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High impact information on POL12

  • Unlike many POL1 and POL12 mutations, which also cause telomere elongation, the pol12-216 mutation described here does not lead to either reduced Pol1 function, increased telomeric single-stranded DNA, or a reduction in telomeric gene silencing [1].
  • We propose that Pol12, together with Stn1, plays a key role in linking telomerase action with the completion of lagging strand synthesis, and in a regulatory step required for telomere capping [1].
  • Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation [1].
  • Here we describe a genetic screen in yeast for mutants with relaxed telomere length regulation, and the identification of Pol12, the B subunit of the DNA polymerase alpha (Pol1)-primase complex, as a new factor involved in this process [1].
  • The function of the B subunit of the complex is unknown, but the Saccharomyces cerevisiae POL12 gene, which encodes this protein, is essential for cell viability [2].

Biological context of POL12


Associations of POL12 with chemical compounds

  • The in vivo analysis of our 18 pol12 alleles indicates that the conserved carboxy-terminal two-thirds of the protein contains regions that are essential for cell viability, while the more divergent NH2-terminal portion is partially dispensable [2].

Other interactions of POL12

  • Moreover, overexpressed Cdc17 that is normally subject to rapid degradation is stabilized by Mcm10 co-overexpression but not by co-overexpression of the B-subunit of pol-alpha, Pol12 [5].


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