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Chemical Compound Review:

Beacon methyl2-[[4,6- bis(difluoromethoxy)pyrimid...

Synonyms: Rifle, Tell, SureCN118690, HSDB 7062, AC-6207, ...

Täpp, I. et al., Lewis, T. et al., Koda, T. et al., Bozaoglu, K. et al., Kleinbard, P., et al.

Orrù, Ferrando, Meloni, Liciardi, Savini, De Santis, Collier, McMillan, Windmill, Walder, Tenne-Brown, de Silva, Trevaskis, Jones, Morton, Lee, Augert, Civitarese, Zimmet, Span, Manders, Heuvel, Thomas, Bosch, Beex, Sweep, Koda, Soya, Negishi, Shiraishi, Morita, Lewis, Abanobi, Alleman, Ballinas, Botbyl, Bries, Clark, Clarkson, Cooper, Cooper, Cox, Cude, Davis, Delosreyes, Durst, East, Edwards, Ellison, Eparwa, Forjuoh, Foster, Foytik, Gordon, Grace, Green, Harrison, Herrera, Horn, Hunsinger, Issac, Jackson, Johnson, Kitayama, Karaan, Kezmarski, Kleinrock, Latson, Lee, Long, Macapagal, Magsino, Manojkumar, Martin, Matura, McCarthy, McClellan, McDaniel, Mengo, Meurer, Muttathottil, Osayande, Osei-Frimpong, Phillips, Pittman, Pratt, Putney, Refuerzo, Rendon, Richter, Simms, Sitoy, Small-Nelson, Sosa, Stuckey, Tacquard, Talbott, Talladen, Taylor, Thomas, Thompson, Walters, West, Nowak, Ruciński, Kaczmarek, Szkudelski, Malendowicz, Postma, Bonants, Van Os, Walder, Segal, Jowett, Blangero, Collier,

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Disease relevance of Beacon

CONCLUSIONS: Expression of hCGbeta-3, -5, -8, which differ by only one nucleotide from other hCGbeta genes, can be assessed by our modified Molecular Beacon assay in breast cancer tissues [1].
Using this strategy, we have identified Beacon as a potential new target for obesity and diabetes [2].
Rapid detection and quantitation of Bluetongue virus (BTV) using a Molecular Beacon fluorescent probe assay [3].
Hypothalamic BEACON gene expression was positively correlated with percentage of body fat, and intracerebroventricular infusion of the Beacon protein resulted in a dose-dependent increase in food intake and body weight [4].

Psychiatry related information on Beacon

Successful Beacon programs provide positive ways to meet young people's need for safety, a sense of belonging, and mastery; they also provide opportunities for decision making and contributing to others [5].

High impact information on Beacon

In this study, we describe a novel gene that encodes a small protein we have termed "beacon." Beacon mRNA gene expression in the hypothalamus was positively correlated with percentage of body fat [6].
A competitive enzyme-linked immunosorbent assay (ELISA) with estrogen receptor (alpha) and a fluorescence depolarization method with Full-Range Beacon were examined as estrogen receptor binding assays to prescreen endocrine-disrupting chemicals (EDCs) [7].
We compared the performance of the homogeneous TaqMan 5'-nuclease assay and the Molecular Beacon assay using three SNPs in the human estrogen receptor gene as targets [8].
The Molecular Beacon probes distinguished better than the TaqMan probes between homozygous and heterozygous genotypes of a C-to-G transversion in codon 325 [8].
OBJECTIVE: Beacon gene expression is elevated in the hypothalamus of the Israeli sand rat (Psammomys obesus), an animal that is used as a polygenic animal model of obesity and NIDDM [9].

Biological context of Beacon

Homogeneous scoring of single-nucleotide polymorphisms: comparison of the 5'-nuclease TaqMan assay and Molecular Beacon probes [8].

Analytical, diagnostic and therapeutic context of Beacon

In addition, real-time quantitative PCR using a Molecular Beacon probe was designed and tested [10].
This article features the Coronary Care Unit of The Methodist Hospital of Houston, Texas. This unit was one of the first Beacon Critical Care Units recognized by the American Association of Critical Care Nurses. This article focuses on how to achieve this award [11].

References

Molecular beacon reverse transcription-PCR of human chorionic gonadotropin-beta-3, -5, and -8 mRNAs has prognostic value in breast cancer. Span, P.N., Manders, P., Heuvel, J.J., Thomas, C.M., Bosch, R.R., Beex, L.V., Sweep, C.G. Clin. Chem. (2003) [Pubmed]
Obesity and diabetes gene discovery approaches. Walder, K., Segal, D., Jowett, J., Blangero, J., Collier, G.R. Curr. Pharm. Des. (2003) [Pubmed]
Rapid detection and quantitation of Bluetongue virus (BTV) using a Molecular Beacon fluorescent probe assay. Orrù, G., Ferrando, M.L., Meloni, M., Liciardi, M., Savini, G., De Santis, P. J. Virol. Methods (2006) [Pubmed]
Association of genetic variation within UBL5 with phenotypes of metabolic syndrome. Bozaoglu, K., Curran, J.E., Elliott, K.S., Walder, K.R., Dyer, T.D., Rainwater, D.L., VandeBerg, J.L., Comuzzie, A.G., Collier, G.R., Zimmet, P., MacCluer, J.W., Jowett, J.B., Blangero, J. Hum. Biol. (2006) [Pubmed]
The New York City Beacons: rebuilding communities of support in urban neighborhoods. Kleinbard, P. New directions for youth development. (2005) [Pubmed]
Beacon: a novel gene involved in the regulation of energy balance. Collier, G.R., McMillan, J.S., Windmill, K., Walder, K., Tenne-Brown, J., de Silva, A., Trevaskis, J., Jones, S., Morton, G.J., Lee, S., Augert, G., Civitarese, A., Zimmet, P.Z. Diabetes (2000) [Pubmed]
Improvement of a sensitive enzyme-linked immunosorbent assay for screening estrogen receptor binding activity. Koda, T., Soya, Y., Negishi, H., Shiraishi, F., Morita, M. Environ. Toxicol. Chem. (2002) [Pubmed]
Homogeneous scoring of single-nucleotide polymorphisms: comparison of the 5'-nuclease TaqMan assay and Molecular Beacon probes. Täpp, I., Malmberg, L., Rennel, E., Wik, M., Syvänen, A.C. BioTechniques (2000) [Pubmed]
Expression of the beacon gene in the rat pancreatic islets: opposite effects of beacon (47-73) protein (ubiquitin-like protein 5) on insulin secretion in vivo and insulin release by isolated islets. Nowak, K.W., Ruciński, M., Kaczmarek, P., Szkudelski, T., Malendowicz, L.K. Pancreas (2004) [Pubmed]
Population dynamics of Pythium aphanidermatum in cucumber grown in closed systems. Postma, J., Bonants, P.J., Van Os, E.A. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) (2001) [Pubmed]
The Methodist Hospital CCU: a Beacon unit of excellence. Lewis, T., Abanobi, B., Alleman, P., Ballinas, E., Botbyl, B., Bries, G., Clark, L., Clarkson, T., Cooper, B., Cooper, J., Cox, S., Cude, R., Davis, J., Delosreyes, A., Durst, K., East, A., Edwards, E., Ellison, R., Eparwa, P., Forjuoh, H., Foster, D., Foytik, L., Gordon, M., Grace, J., Green, L., Harrison, C., Herrera, R., Horn, M., Hunsinger, C., Issac, A., Jackson, V., Johnson, A., Kitayama, S., Karaan, J., Kezmarski, M., Kleinrock, R., Latson, M., Lee, V., Long, R., Macapagal, F., Magsino, D., Manojkumar, S., Martin, D., Matura, L.A., McCarthy, C., McClellan, E., McDaniel, C., Mengo, P., Meurer, J., Muttathottil, L., Osayande, E., Osei-Frimpong, D., Phillips, B., Pittman, J., Pratt, C., Putney, D., Refuerzo, L., Rendon, L., Richter, R., Simms, S., Sitoy, D., Small-Nelson, J., Sosa, T., Stuckey, D., Tacquard, N., Talbott, S., Talladen, A., Taylor, S., Thomas, L., Thompson, P., Walters, G., West, R. Critical care nursing clinics of North America. (2005) [Pubmed]

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