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Gene Review

KIN1  -  Kin1p

Saccharomyces cerevisiae S288c

Synonyms: Serine/threonine protein kinase KIN1, YD9727.17, YDR122W
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High impact information on KIN1


Biological context of KIN1

  • KIN1 and KIN2 are transcribed into 3.5-kilobase mRNAs that contain uninterrupted open reading frames encoding polypeptides of 117 kDa and 126 kDa, respectively [1].
  • Two genes, KIN1 and KIN2, were isolated in Saccharomyces cerevisiae by their homology to the protein kinase family of viral oncogenes [4].
  • These findings show that the C. neoformans Kin1 kinase homologue is required for full virulence in disparate hosts and that C. elegans can be used as a substitute host to identify novel factors involved in fungal pathogenesis in mammals [2].

Anatomical context of KIN1


Associations of KIN1 with chemical compounds

  • In exponentially growing yeast cells, the KIN1 protein is phosphorylated primarily on serine residues [5].

Other interactions of KIN1

  • Here, we present evidence for a novel link between Kin1, Kin2, and the secretory machinery of the budding yeast [6].
  • We have independently identified and DNA sequenced the INO2 locus by its close proximity to the KIN1 locus in Saccharomyces cerevisiae [7].

Analytical, diagnostic and therapeutic context of KIN1

  • Using antibodies raised against a bacterial LacZ/KIN1 fusion protein, we have identified by immunoprecipitation the yeast KIN1 gene product as a 145,000 dalton protein (p145KIN1) [5].


  1. Two yeast genes that encode unusual protein kinases. Levin, D.E., Hammond, C.I., Ralston, R.O., Bishop, J.M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. Mylonakis, E., Idnurm, A., Moreno, R., El Khoury, J., Rottman, J.B., Ausubel, F.M., Heitman, J., Calderwood, S.B. Mol. Microbiol. (2004) [Pubmed]
  3. Characterization of the KIN2 gene product in Saccharomyces cerevisiae and comparison between the kinase activities of p145KIN1 and p145KIN2. Donovan, M., Romano, P., Tibbetts, M., Hammond, C.I. Yeast (1994) [Pubmed]
  4. KIN1 and KIN2 protein kinases localize to the cytoplasmic face of the yeast plasma membrane. Tibbetts, M., Donovan, M., Roe, S., Stiltner, A.M., Hammond, C.I. Exp. Cell Res. (1994) [Pubmed]
  5. The product of the KIN1 locus in Saccharomyces cerevisiae is a serine/threonine-specific protein kinase. Lamb, A., Tibbetts, M., Hammond, C.I. Yeast (1991) [Pubmed]
  6. The yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machinery. Elbert, M., Rossi, G., Brennwald, P. Mol. Biol. Cell (2005) [Pubmed]
  7. INO2, a regulatory gene in yeast phospholipid biosynthesis, affects nuclear segregation and bud pattern formation. Hammond, C.L., Romano, P., Roe, S., Tontonoz, P. Cell. Mol. Biol. Res. (1993) [Pubmed]
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