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Gene Review

RVB1  -  RuvB family ATP-dependent DNA helicase pontin

Saccharomyces cerevisiae S288c

Synonyms: RUVBL1, RuvB-like protein 1, TIH1, TIP49, TIP49-homology protein 1, ...
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High impact information on RVB1

  • These cofactors interact physically and functionally with the conserved AAA(+)-type DNA helicases Rvb1/Rvb2, which are key components of several chromatin remodeling factors, thereby linking Hsp90 to epigenetic gene regulation [1].
  • Loss of Rvb1p or Ino80p affects many yeast promoters similarly [2].
  • The TIP49 and TIP48 ATPase/helicase proteins represent a novel class of cofactors recruited by transcriptional activation domains that function in diverse pathways [3].
  • ATP binding and hydrolysis by Rvb1p and Rvb2p is individually essential in vivo, and the two proteins are associated with each other in a high molecular weight complex that shows ATP-dependent chromatin remodeling activity in vitro [4].
  • In addition, two yeast homologs, scRUVBL1 and scRUVBL2 with 70 and 42% identity to RUVBL1, respectively, were revealed by screening the complete Saccharomyces cerevisiae genome sequence [5].

Biological context of RVB1


Physical interactions of RVB1

  • Immunoprecipitation analysis revealed that Tih2p tightly interacts with Tih1p, the counterpart of mammalian p50/TIP49a, which has been shown to interact with the TATA-binding protein and the RNA polymerase II holoenzyme complex [7].

Analytical, diagnostic and therapeutic context of RVB1

  • Fluorescence in situ hybridization analysis demonstrated that the RUVBL1 gene is located at 3q21, a region with frequent rearrangements in different types of leukemia and solid tumors [5].


  1. Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Zhao, R., Davey, M., Hsu, Y.C., Kaplanek, P., Tong, A., Parsons, A.B., Krogan, N., Cagney, G., Mai, D., Greenblatt, J., Boone, C., Emili, A., Houry, W.A. Cell (2005) [Pubmed]
  2. Rvb1p/Rvb2p recruit Arp5p and assemble a functional Ino80 chromatin remodeling complex. Jónsson, Z.O., Jha, S., Wohlschlegel, J.A., Dutta, A. Mol. Cell (2004) [Pubmed]
  3. An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. Wood, M.A., McMahon, S.B., Cole, M.D. Mol. Cell (2000) [Pubmed]
  4. Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes. Jónsson, Z.O., Dhar, S.K., Narlikar, G.J., Auty, R., Wagle, N., Pellman, D., Pratt, R.E., Kingston, R., Dutta, A. J. Biol. Chem. (2001) [Pubmed]
  5. An eukaryotic RuvB-like protein (RUVBL1) essential for growth. Qiu, X.B., Lin, Y.L., Thome, K.C., Pian, P., Schlegel, B.P., Weremowicz, S., Parvin, J.D., Dutta, A. J. Biol. Chem. (1998) [Pubmed]
  6. Impairment of the DNA binding activity of the TATA-binding protein renders the transcriptional function of Rvb2p/Tih2p, the yeast RuvB-like protein, essential for cell growth. Ohdate, H., Lim, C.R., Kokubo, T., Matsubara, K., Kimata, Y., Kohno, K. J. Biol. Chem. (2003) [Pubmed]
  7. The Saccharomyces cerevisiae RuvB-like protein, Tih2p, is required for cell cycle progression and RNA polymerase II-directed transcription. Lim, C.R., Kimata, Y., Ohdate, H., Kokubo, T., Kikuchi, N., Horigome, T., Kohno, K. J. Biol. Chem. (2000) [Pubmed]
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