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Gene Review

INO80  -  chromatin-remodeling ATPase INO80

Saccharomyces cerevisiae S288c

Synonyms: G1880, Inositol-requiring protein 80, YGL150C
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Disease relevance of INO80


High impact information on INO80

  • Finally, components of the INO80 complex show synthetic genetic interactions with the RAD52 DNA repair pathway, the main pathway for DSB repair in yeast [2].
  • Finally, we demonstrate that conversion of the DSB into ssDNA is compromised in arp8 and H2A mutants, which are both deficient for INO80 activity at the site of damage [3].
  • This interaction requires Nhp10, an HMG-like subunit of the INO80 complex [2].
  • The INO80 complex is recruited to a HO endonuclease-induced DSB through a specific interaction with the DNA damage-induced phosphorylated histone H2A (gamma-H2AX) [2].
  • The budding yeast INO80 complex is a conserved ATP-dependent nucleosome remodeler containing actin-related proteins Arp5 and Arp8 [3].

Biological context of INO80


Associations of INO80 with chemical compounds


Physical interactions of INO80

  • The INO80 complex contains about 12 polypeptides including two proteins related to the bacterial RuvB DNA helicase, which catalyses branch migration of Holliday junctions [1].

Other interactions of INO80


Analytical, diagnostic and therapeutic context of INO80


  1. A chromatin remodelling complex involved in transcription and DNA processing. Shen, X., Mizuguchi, G., Hamiche, A., Wu, C. Nature (2000) [Pubmed]
  2. INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Morrison, A.J., Highland, J., Krogan, N.J., Arbel-Eden, A., Greenblatt, J.F., Haber, J.E., Shen, X. Cell (2004) [Pubmed]
  3. Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair. van Attikum, H., Fritsch, O., Hohn, B., Gasser, S.M. Cell (2004) [Pubmed]
  4. In silico characterization of the INO80 subfamily of SWI2/SNF2 chromatin remodeling proteins. Bakshi, R., Prakash, T., Dash, D., Brahmachari, V. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  5. The product of the SNF2/SWI2 paralogue INO80 of Saccharomyces cerevisiae required for efficient expression of various yeast structural genes is part of a high-molecular-weight protein complex. Ebbert, R., Birkmann, A., Schüller, H.J. Mol. Microbiol. (1999) [Pubmed]
  6. Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates. Shen, X., Xiao, H., Ranallo, R., Wu, W.H., Wu, C. Science (2003) [Pubmed]
  7. Regulation of chromatin remodeling by inositol polyphosphates. Steger, D.J., Haswell, E.S., Miller, A.L., Wente, S.R., O'Shea, E.K. Science (2003) [Pubmed]
  8. Rvb1p/Rvb2p recruit Arp5p and assemble a functional Ino80 chromatin remodeling complex. Jónsson, Z.O., Jha, S., Wohlschlegel, J.A., Dutta, A. Mol. Cell (2004) [Pubmed]
  9. A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin. Kobor, M.S., Venkatasubrahmanyam, S., Meneghini, M.D., Gin, J.W., Jennings, J.L., Link, A.J., Madhani, H.D., Rine, J. PLoS Biol. (2004) [Pubmed]
  10. Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling. Javaheri, A., Wysocki, R., Jobin-Robitaille, O., Altaf, M., Côté, J., Kron, S.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  11. Anc1 interacts with the catalytic subunits of the general transcription factors TFIID and TFIIF, the chromatin remodeling complexes RSC and INO80, and the histone acetyltransferase complex NuA3. Kabani, M., Michot, K., Boschiero, C., Werner, M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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