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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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RVB2  -  RuvB family ATP-dependent DNA helicase reptin

Saccharomyces cerevisiae S288c

Synonyms: P1060, RUVBL2, RuvB-like protein 2, TIH2, TIP48, ...
 
 
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High impact information on RVB2

  • These cofactors interact physically and functionally with the conserved AAA(+)-type DNA helicases Rvb1/Rvb2, which are key components of several chromatin remodeling factors, thereby linking Hsp90 to epigenetic gene regulation [1].
  • Rvb2p associates with Arp5p in vitro in a reaction dependent on the presence of ATP and Ino80p [2].
  • The TIP49 and TIP48 ATPase/helicase proteins represent a novel class of cofactors recruited by transcriptional activation domains that function in diverse pathways [3].
  • Findings from other studies link Rvb2 orthologs with chromatin remodeling and transcription [4].
  • Taken together, the present results indicate that Rvb2 is involved in an early stage of snoRNP biogenesis and may play a role in coupling snoRNA synthesis with snoRNP assembly and localization [4].
 

Biological context of RVB2

  • Impairment of the DNA binding activity of the TATA-binding protein renders the transcriptional function of Rvb2p/Tih2p, the yeast RuvB-like protein, essential for cell growth [5].
  • Furthermore, the mutational study of the Walker A motif, which is required for nucleotide binding and hydrolysis, showed that this motif plays indispensable roles in the function of Tih2p [6].
  • The similarities between the mutant phenotypes of tih2-160 and those of taf145 mutants suggest a role for TIH2 in the regulation of RNA polymerase II-directed transcription [6].
  • The Saccharomyces cerevisiae RuvB-like protein, Tih2p, is required for cell cycle progression and RNA polymerase II-directed transcription [6].
 

Physical interactions of RVB2

  • Immunoprecipitation analysis revealed that Tih2p tightly interacts with Tih1p, the counterpart of mammalian p50/TIP49a, which has been shown to interact with the TATA-binding protein and the RNA polymerase II holoenzyme complex [6].
 

Other interactions of RVB2

  • This suggests that Tih2p might be important in recruiting TBP to the promoter [5].
 

Analytical, diagnostic and therapeutic context of RVB2

  • Northern blot analysis revealed that Tih2p is required for transcription of G(1) cyclin and of several ribosomal protein genes [6].

References

  1. Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Zhao, R., Davey, M., Hsu, Y.C., Kaplanek, P., Tong, A., Parsons, A.B., Krogan, N., Cagney, G., Mai, D., Greenblatt, J., Boone, C., Emili, A., Houry, W.A. Cell (2005) [Pubmed]
  2. Rvb1p/Rvb2p recruit Arp5p and assemble a functional Ino80 chromatin remodeling complex. Jónsson, Z.O., Jha, S., Wohlschlegel, J.A., Dutta, A. Mol. Cell (2004) [Pubmed]
  3. An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. Wood, M.A., McMahon, S.B., Cole, M.D. Mol. Cell (2000) [Pubmed]
  4. A well-connected and conserved nucleoplasmic helicase is required for production of box C/D and H/ACA snoRNAs and localization of snoRNP proteins. King, T.H., Decatur, W.A., Bertrand, E., Maxwell, E.S., Fournier, M.J. Mol. Cell. Biol. (2001) [Pubmed]
  5. Impairment of the DNA binding activity of the TATA-binding protein renders the transcriptional function of Rvb2p/Tih2p, the yeast RuvB-like protein, essential for cell growth. Ohdate, H., Lim, C.R., Kokubo, T., Matsubara, K., Kimata, Y., Kohno, K. J. Biol. Chem. (2003) [Pubmed]
  6. The Saccharomyces cerevisiae RuvB-like protein, Tih2p, is required for cell cycle progression and RNA polymerase II-directed transcription. Lim, C.R., Kimata, Y., Ohdate, H., Kokubo, T., Kikuchi, N., Horigome, T., Kohno, K. J. Biol. Chem. (2000) [Pubmed]
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