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Gene Review

PAD1  -  phenylacrylic acid decarboxylase PAD1

Saccharomyces cerevisiae S288c

Synonyms: PAD, POF1, Phenylacrylic acid decarboxylase 1, mitochondrial, YDR538W
 
 
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Disease relevance of PAD1

  • Crystal structure of a dodecameric FMN-dependent UbiX-like decarboxylase (Pad1) from Escherichia coli O157: H7 [1].
 

High impact information on PAD1

 

Biological context of PAD1

  • The decomposition rate of ferulic acid correlated with POF production and the critical concentration of phenolic acid (free form) in grape must was estimated to be more than 10 mg/l. Segregation of POF phenotype and Southern blot analysis of phenolic wine yeasts suggest that POF production is controlled by the POF gene (PAD1) [4].
  • PAD1 is a single-copy gene in the yeast genome and not essential for viability [3].
  • Taken together, these results suggest that SmPOH, and possibly other related Pad1 proteins, function as positive modulators of transcription by increasing the stability of cellular c-Jun, making elevated amounts of this protein available for transactivation of AP-1-responsive genes [5].
 

Associations of PAD1 with chemical compounds

  • The Pad1p overexpressing transformants also showed a 22-25% faster glucose consumption rate, a 40-45% faster mannose consumption rate, and a 24-29% faster ethanol production rate in the dilute acid hydrolysate of spruce [6].

References

  1. Crystal structure of a dodecameric FMN-dependent UbiX-like decarboxylase (Pad1) from Escherichia coli O157: H7. Rangarajan, E.S., Li, Y., Iannuzzi, P., Tocilj, A., Hung, L.W., Matte, A., Cygler, M. Protein Sci. (2004) [Pubmed]
  2. The STL1 gene of Saccharomyces cerevisiae is predicted to encode a sugar transporter-like protein. Zhao, S., Douglas, N.W., Heine, M.J., Williams, G.M., Winther-Larsen, H.C., Meaden, P.G. Gene (1994) [Pubmed]
  3. PAD1 encodes phenylacrylic acid decarboxylase which confers resistance to cinnamic acid in Saccharomyces cerevisiae. Clausen, M., Lamb, C.J., Megnet, R., Doerner, P.W. Gene (1994) [Pubmed]
  4. Distribution of phenolic yeasts and production of phenolic off-flavors in wine fermentation. Shinohara, T., Kubodera, S., Yanagida, F. J. Biosci. Bioeng. (2000) [Pubmed]
  5. A Schistosoma mansoni Pad1 homologue stabilizes c-Jun. Nabhan, J.F., Hamdan, F.F., Ribeiro, P. Mol. Biochem. Parasitol. (2002) [Pubmed]
  6. Effect of overexpression of Saccharomyces cerevisiae Pad1p on the resistance to phenylacrylic acids and lignocellulose hydrolysates under aerobic and oxygen-limited conditions. Larsson, S., Nilvebrant, N.O., Jönsson, L.J. Appl. Microbiol. Biotechnol. (2001) [Pubmed]
 
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