High impact information on STL1

• That Stl1p and Stl2p are functional homologues of Sec12p was confirmed by showing that expression of either cloned gene complements a sec12 null mutation [1].
• Overexpression of SMP1 induced Hog1-dependent expression of osmoresponsive genes such as STL1, whereas smp1Delta cells were defective in their expression [2].
• In S. pombe, STL1 conferred the ability to take up glycerol against a concentration gradient in a proton motive force-dependent manner [3].
• Stl1p is present in the plasma membrane in S. cerevisiae during conditions where glycerol symport is functional [3].
• This gene, STL1, was identified as an open reading frame (ORF) closely linked to the cinnamic-acid-resistance gene POF1 on chromosome IV [4].

Associations of STL1 with chemical compounds

• Disruption of STL1 had no detectable effect on yeast growth on glucose, galactose, mannose, maltose or glycerol as sole carbon source [4].
• Deletion of STL1, which encodes a member of the sugar transporter family, eliminates active glycerol transport [3].

Other interactions of STL1

• In contrast, the lumenal domains of Sec12p, Stl1p and Stl2p are very different in size and do not show any appreciable homology [1].

References