The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ECM33  -  Ecm33p

Saccharomyces cerevisiae S288c

Synonyms: Cell wall protein ECM33, Extracellular mutant protein 33, YBR0727, YBR078W
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ECM33


Biological context of ECM33

  • Suppressors commonly effective to mpc1-4 and mpc1-5 mutations are PSD1, encoding phosphatidylserine decarboxylase, and ECM33, which were found to suppress the temperature-sensitive phenotype shown by the fsr2-1 and las21delta mutants, those of which have defects in the GPI anchor synthesis [6].
  • Ecm33p, a GPI-anchored protein involved in cell wall biogenesis, has been found for the first time in lipid rafts [7].
  • To identify potential mechanisms through which Ecm33p contributes to virulence, we investigated the interactions of C. albicans ecm33Delta mutants with endothelial cells and the FaDu oral epithelial cell line in vitro [8].

Anatomical context of ECM33


  1. Glycosylphosphatidylinositol-Anchored Ecm33p Influences Conidial Cell Wall Biosynthesis in Aspergillus fumigatus. Chabane, S., Sarfati, J., Ibrahim-Granet, O., Du, C., Schmidt, C., Mouyna, I., Prevost, M.C., Calderone, R., Latgé, J.P. Appl. Environ. Microbiol. (2006) [Pubmed]
  2. PST1 and ECM33 encode two yeast cell surface GPI proteins important for cell wall integrity. Pardo, M., Monteoliva, L., Vázquez, P., Martínez, R., Molero, G., Nombela, C., Gil, C. Microbiology (Reading, Engl.) (2004) [Pubmed]
  3. The GPI-anchored protein CaEcm33p is required for cell wall integrity, morphogenesis and virulence in Candida albicans. Martinez-Lopez, R., Monteoliva, L., Diez-Orejas, R., Nombela, C., Gil, C. Microbiology (Reading, Engl.) (2004) [Pubmed]
  4. Sequence analysis of a 31 kb DNA fragment from the right arm of Saccharomyces cerevisiae chromosome II. Van der Aart, Q.J., Barthe, C., Doignon, F., Aigle, M., Crouzet, M., Steensma, H.Y. Yeast (1994) [Pubmed]
  5. The localization change of Ybr078w/Ecm33, a yeast GPI-associated protein, from the plasma membrane to the cell wall, affecting the cellular function. Terashima, H., Hamada, K., Kitada, K. FEMS Microbiol. Lett. (2003) [Pubmed]
  6. Genetic characterization of genes encoding enzymes catalyzing addition of phospho-ethanolamine to the glycosylphosphatidylinositol anchor in Saccharomyces cerevisiae. Toh-e, A., Oguchi, T. Genes Genet. Syst. (2002) [Pubmed]
  7. Proteomic analysis of detergent-resistant membranes from Candida albicans. Insenser, M., Nombela, C., Molero, G., Gil, C. Proteomics (2006) [Pubmed]
  8. Candida albicans Ecm33p is important for normal cell wall architecture and interactions with host cells. Martinez-Lopez, R., Park, H., Myers, C.L., Gil, C., Filler, S.G. Eukaryotic Cell (2006) [Pubmed]
WikiGenes - Universities