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Gene Review

RGD1  -  Rgd1p

Saccharomyces cerevisiae S288c

Synonyms: RHO GTPase-activating protein RGD1, Related GAP domain protein 1, RhoGAP, YBR1728, YBR260C
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High impact information on RGD1

  • Genetic relationships between either VRP1 or RGD1 and actin cytoskeleton-linked genes were also studied [1].
  • The non-essential RGD1 gene from Saccharomyces cerevisiae encodes a protein that has been characterized in vitro as a Rho GTPase activating protein (RhoGAP) for the Rho3 and Rho4 proteins [1].
  • To better understand the role of Rgd1p, we isolated multicopy suppressor genes of the cell lethality of the double mutant rgd1Delta mid2Delta [2].
  • The RhoGAP Rgd1p is involved in different signal transduction pathways in Saccharomyces cerevisiae through its regulatory activity upon the Rho3 and Rho4 GTPases [3].
  • RGD1, encoding a RhoGAP involved in low-pH survival, is an Msn2p/Msn4p regulated gene in Saccharomyces cerevisiae [3].

Biological context of RGD1


Anatomical context of RGD1


Associations of RGD1 with chemical compounds

  • As for mutants altered in PKC pathway, the accumulation of small-budded dead cells in slg1, rgd1 and mid2 after heat shock was prevented by 1 M sorbitol [4].

Regulatory relationships of RGD1


Other interactions of RGD1

  • In contrast, the genetic interaction between RGD1 and MID2 was not due to an accumulation of GTP-bound Rho proteins [7].
  • Rgd1, a GTPase-activating protein, is the only known negative regulator of the Rho3 and Rho4 small GTPases in the yeast Saccharomyces cerevisiae [7].
  • It was proposed that simultaneous inactivation of RGD1 and WSC1 constitutively activates the PKC-mitogen-activated protein kinase (MAP kinase) pathway [7].
  • YBR1733 is homologous to rab protein and YBR1728 is presumably a GTPase activating protein [8].


  1. Evidence for the genetic interaction between the actin-binding protein Vrp1 and the RhoGAP Rgd1 mediated through Rho3p and Rho4p in Saccharomyces cerevisiae. Roumanie, O., Peypouquet, M.F., Bonneu, M., Thoraval, D., Doignon, F., Crouzet, M. Mol. Microbiol. (2000) [Pubmed]
  2. Overactivation of the protein kinase C-signaling pathway suppresses the defects of cells lacking the Rho3/Rho4-GAP Rgd1p in Saccharomyces cerevisiae. de Bettignies, G., Thoraval, D., Morel, C., Peypouquet, M.F., Crouzet, M. Genetics (2001) [Pubmed]
  3. RGD1, encoding a RhoGAP involved in low-pH survival, is an Msn2p/Msn4p regulated gene in Saccharomyces cerevisiae. Gatti, X., de Bettignies, G., Claret, S., Doignon, F., Crouzet, M., Thoraval, D. Gene (2005) [Pubmed]
  4. RGD1 genetically interacts with MID2 and SLG1, encoding two putative sensors for cell integrity signalling in Saccharomyces cerevisiae. de Bettignies, G., Barthe, C., Morel, C., Peypouquet, M.F., Doignon, F., Crouzet, M. Yeast (1999) [Pubmed]
  5. First characterization of the gene RGD1 in the yeast Saccharomyces cerevisiae. Barthe, C., de Bettignies, G., Louvet, O., Peypouquet, M.F., Morel, C., Doignon, F., Crouzet, M. C. R. Acad. Sci. III, Sci. Vie (1998) [Pubmed]
  6. The Rgd1p Rho GTPase-activating protein and the Mid2p cell wall sensor are required at low pH for protein kinase C pathway activation and cell survival in Saccharomyces cerevisiae. Claret, S., Gatti, X., Doignon, F., Thoraval, D., Crouzet, M. Eukaryotic Cell (2005) [Pubmed]
  7. The Rho3 and Rho4 small GTPases interact functionally with Wsc1p, a cell surface sensor of the protein kinase C cell-integrity pathway in Saccharomyces cerevisiae. Fernandes, H., Roumanie, O., Claret, S., Gatti, X., Thoraval, D., Doignon, F., Crouzet, M. Microbiology (Reading, Engl.) (2006) [Pubmed]
  8. The complete sequence of a 19,482 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae. Doignon, F., Biteau, N., Crouzet, M., Aigle, M. Yeast (1993) [Pubmed]
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