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Gene Review

SUL1  -  Sul1p

Saccharomyces cerevisiae S288c

Synonyms: High-affinity sulfate transporter 1, SFP2, Sulfate permease 1, YBR2110, YBR294W
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High impact information on SUL1


Biological context of SUL1

  • This mutant was unable to grow on media containing less than 5 mM sulphate unless complemented with a plasmid containing the SUL1 cDNA [5].
  • Sequence motifs within the deduced amino acid sequence of this cDNA (SUL1) show homology with conserved areas of sulphate transport proteins from other organisms [5].
  • Southern blot analysis revealed that SFP2 exists as a single copy in haploid genome [6].

Anatomical context of SUL1

  • We conclude that the SUL1 cDNA encodes a S. cerevisiae high affinity sulphate transporter that is responsible for the transfer of sulphate across the plasma membrane from the external medium [5].

Analytical, diagnostic and therapeutic context of SUL1

  • Sequence analysis predicts the position of 12 putative membrane spanning domains in SUL1 [5].
  • Northern blot analysis showed that SFP2 produced a 2.8-kb transcript which was highly expressed under sulfur derepressing condition [6].


  1. Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Novick, P., Field, C., Schekman, R. Cell (1980) [Pubmed]
  2. Yeast secretory mutants that block the formation of active cell surface enzymes. Ferro-Novick, S., Novick, P., Field, C., Schekman, R. J. Cell Biol. (1984) [Pubmed]
  3. Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Novick, P., Schekman, R. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  4. Nucleotide sequence, messenger RNA stability, and DNA recognition elements of cys-14, the structural gene for sulfate permease II in Neurospora crassa. Ketter, J.S., Jarai, G., Fu, Y.H., Marzluf, G.A. Biochemistry (1991) [Pubmed]
  5. Isolation of a cDNA from Saccharomyces cerevisiae that encodes a high affinity sulphate transporter at the plasma membrane. Smith, F.W., Hawkesford, M.J., Prosser, I.M., Clarkson, D.T. Mol. Gen. Genet. (1995) [Pubmed]
  6. Characterization of SFP2, a putative sulfate permease gene of Saccharomyces cerevisiae. Jin, Y.H., Jang, Y.K., Kim, M.J., Rad, M.R., Kirchrath, L., Seong, R.H., Hong, S.H., Hollenberg, C.P., Park, S.D. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
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