High impact information on HOS2

• Finally, Hos1/Hos3 and Hos2 preferentially affect ribosomal DNA and ribosomal protein genes, respectively [1].
• In support of this conclusion, gcn5Deltaelp3Delta phenotypes are suppressed by concomitant mutation of the HDA1 and HOS2 histone deacetylases [2].
• A gene related to yeast HOS2 histone deacetylase affects extracellular depolymerase expression and virulence in a plant pathogenic fungus [3].
• A gene, HDC1, related to the Saccharomyces cerevisiae histone deacetylase (HDAC) gene HOS2, was isolated from the filamentous fungus Cochliobolus carbonum, a pathogen of maize that makes the HDAC inhibitor HC-toxin [3].
• Histone Deacetylases RPD3 and HOS2 Regulate the Transcriptional Activation of DNA Damage-Inducible Genes [4].

Biological context of HOS2

• Therefore, our data indicate that, in contrast to other class I histone deacetylases, Hos2 is directly required for gene activation [5].

Physical interactions of HOS2

• Rpd3 and Hos2 interact with Ssn6 independently of Tup1 via distinct tetratricopeptide domains within Ssn6, suggesting that these two HDACs may contact the corepressor at the same time [6].

Other interactions of HOS2

• Deletion of HOS2 or SET3 reduced the mobility of a chromosomal Ty1his3AI element about sevenfold [7].
• Here, we describe physical interactions of the corepressor complex with the class I HDACs Rpd3, Hos2, and Hos1 [6].
• We also isolated two transformants identified as the nuclear exportin Msn5 and the histone deacetylase Hos2 extragenic suppressors of this mutation [8].

Analytical, diagnostic and therapeutic context of HOS2

• Chromatin immunoprecipitation analysis revealed that Hos2 is physically associated with tRNA genes [7].

References