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Gene Review:

TPN1 - Tpn1p

Saccharomyces cerevisiae S288c

Synonyms: G1370, Transport of pyridoxine protein 1, Vitamin B6 transporter TPN1, YGL186C

Stolz, J. et al., Paluszynski, J.P. et al.

Stolz, Vielreicher,

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Disease relevance of TPN1

Among these, Tpn1, Fur4 and the one encoded by yOR071c were found to contribute significantly to 5-FC toxicity, thus revealing alternative entry routes for 5-FC via other cytosine/adenine permease homologues [1].

High impact information on TPN1

Moreover, expression of TPN1 was regulated and increased with decreasing concentrations of vitamin B6 in the medium [2].
TPN1 mutants lost the ability to utilize extracellular PN, pyridoxal, and pyridoxamine, showing that there is no other transporter for vitamin B6 encoded in the genome [2].
Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae [2].
Amino acid substitutions that led to a loss of Tpn1p function localized to transmembrane domain 4 within the 12-transmembrane domain protein [2].

References

Various cytosine/adenine permease homologues are involved in the toxicity of 5-fluorocytosine in Saccharomyces cerevisiae. Paluszynski, J.P., Klassen, R., Rohe, M., Meinhardt, F. Yeast (2006) [Pubmed]
Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae. Stolz, J., Vielreicher, M. J. Biol. Chem. (2003) [Pubmed]

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