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Gene Review

RCY1  -  Rcy1p

Saccharomyces cerevisiae S288c

Synonyms: J0318, J0320, Recyclin-1, YJL204C
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Disease relevance of RCY1


High impact information on RCY1

  • Mutation of RCY1 leads to the accumulation of an enlarged compartment that contains the t-SNARE Tlg1p and lies close to areas of cell expansion [2].
  • Deletion of RCY1 leads to an early block in the endocytic pathway before the intersection with the vacuolar protein sorting pathway [2].
  • Importantly, Skp1p was the only major partner that copurified with Rcy1p [3].
  • Rcy1p localized to areas of polarized growth, and this polarized localization required its CAAX box and an intact actin cytoskeleton [3].
  • Unlike the case for F-box proteins that are known to participate in SCF complexes, degradation of Rcy1p required neither its F box nor functional 26S proteasomes or other SCF core subunits [3].

Biological context of RCY1


Physical interactions of RCY1


Regulatory relationships of RCY1


Other interactions of RCY1

  • Three of these genes were identified on the basis of trafficking defects by ourselves and others within the EUROFAN project (TLG2, RCY1, MON2) [6].
  • Our results thus suggest that a complex composed of Rcy1p and Skp1p but not other SCF components may play a direct role in recycling of internalized proteins [3].


  1. Antifungal activity of amiodarone is mediated by disruption of calcium homeostasis. Gupta, S.S., Ton, V.K., Beaudry, V., Rulli, S., Cunningham, K., Rao, R. J. Biol. Chem. (2003) [Pubmed]
  2. The F-box protein Rcy1p is involved in endocytic membrane traffic and recycling out of an early endosome in Saccharomyces cerevisiae. Wiederkehr, A., Avaro, S., Prescianotto-Baschong, C., Haguenauer-Tsapis, R., Riezman, H. J. Cell Biol. (2000) [Pubmed]
  3. Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast. Galan, J.M., Wiederkehr, A., Seol, J.H., Haguenauer-Tsapis, R., Deshaies, R.J., Riezman, H., Peter, M. Mol. Cell. Biol. (2001) [Pubmed]
  4. Ypt31/32 GTPases and their novel F-box effector protein Rcy1 regulate protein recycling. Chen, S.H., Chen, S., Tokarev, A.A., Liu, F., Jedd, G., Segev, N. Mol. Biol. Cell (2005) [Pubmed]
  5. Endocytic recycling in yeast is regulated by putative phospholipid translocases and the ypt31p/32p-rcy1p pathway. Furuta, N., Fujimura-Kamada, K., Saito, K., Yamamoto, T., Tanaka, K. Mol. Biol. Cell (2007) [Pubmed]
  6. Mutants defective in secretory/vacuolar pathways in the EUROFAN collection of yeast disruptants. Avaro, S., Belgareh-Touzé, N., Sibella-Argüelles, C., Volland, C., Haguenauer-Tsapis, R. Yeast (2002) [Pubmed]
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