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Gene Review: 

RPE1  -  ribulose-phosphate 3-epimerase RPE1

Saccharomyces cerevisiae S288c

Synonyms: EPI1, J0731, POS18, PPE, Pentose-5-phosphate 3-epimerase, ...
 
 
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High impact information on RPE1

  • In the present study we have used a real-time PCR-based nascent strand DNA abundance assay to map initiation sites for DNA replication in in vivo human chromosomes around a 13.4 kb region encompassing the putative RPE gene [1].
  • The initiation sites appear to map to similar positions in both cell lines and occur outside the coding regions of the putative RPE gene [1].
  • For that reason the gene was renamed RPE1 (for ribulose 5-phosphate epimerase) [2].
  • RPE1 was localized to chromosome X. The predicted protein has a molecular mass of 25966 Daltons, a codon adaptation index (CAI) of 0.32, and an isoelectric point of 5.82 [2].
  • The second mutation, pos18, was complemented by transformation with a yeast genomic library [2].
 

Associations of RPE1 with chemical compounds

References

  1. Initiation sites for human DNA replication at a putative ribulose-5-phosphate 3-epimerase gene. Hu, L., Xu, X., Valenzuela, M.S. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  2. Mutants that show increased sensitivity to hydrogen peroxide reveal an important role for the pentose phosphate pathway in protection of yeast against oxidative stress. Juhnke, H., Krems, B., Kötter, P., Entian, K.D. Mol. Gen. Genet. (1996) [Pubmed]
  3. Cloning and characterization of the first two genes of the non-oxidative part of the Saccharomyces cerevisiae pentose-phosphate pathway. Miosga, T., Zimmermann, F.K. Curr. Genet. (1996) [Pubmed]
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