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Gene Review

RKI1  -  ribose-5-phosphate isomerase RKI1

Saccharomyces cerevisiae S288c

Synonyms: D-ribose-5-phosphate ketol-isomerase, Phosphoriboisomerase, Ribose-5-phosphate isomerase, YOR095C, YOR3174C
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Disease relevance of RKI1


High impact information on RKI1

  • Pea chloroplastic phosphoribulokinase and yeast phosphoriboisomerase partition independently of one another in a two-phase polyethyleneglycol, dextran system, but apparent interaction is seen when ribose-5-phosphate is added to the two-phase system [2].
  • Ribose-5-phosphate isomerase A has an important role in sugar metabolism by interconverting ribose-5-phosphate and ribulose-5-phosphate [3].
  • On the basis of the conserved amino acids an alignment of the amino acid sequence of ribose-5-phosphate isomerase from yeast with those of the enzyme from mouse, spinach and Escherichia coli is presented [4].
  • The molecular mass of the subunit and the identified N-terminal sequence of 33 amino acids fits well the 258 amino acid protein encoded by the S. cerevisiae RKI open reading frame, which was characterized previously only by increasing specific activities of ribose-5-phosphate isomerase in cells after cloning the gene [4].
  • Synthesis of [32P]ADPribulose from [32P]NAD+ by the combined activities of commercial NAD+ glycohydrolase and phosphoriboisomerase allowed us to use it as a labeled internal standard throughout the procedure of purification from trichloroacetic acid extracts of human red blood cells [5].

Biological context of RKI1


Associations of RKI1 with chemical compounds


  1. Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits. Bumann, M., Djafarzadeh, S., Oberholzer, A.E., Bigler, P., Altmann, M., Trachsel, H., Baumann, U. J. Biol. Chem. (2004) [Pubmed]
  2. Chloroplast phosphoribulokinase associates with yeast phosphoriboisomerase in the presence of substrate. Skrukrud, C.L., Anderson, L.E. FEBS Lett. (1991) [Pubmed]
  3. Crystal structure of the S. cerevisiae D-ribose-5-phosphate isomerase: comparison with the archaeal and bacterial enzymes. Graille, M., Meyer, P., Leulliot, N., Sorel, I., Janin, J., Van Tilbeurgh, H., Quevillon-Cheruel, S. Biochimie (2005) [Pubmed]
  4. Ribose-5-phosphate isomerase from Saccharomyces cerevisiae: purification and molecular analysis of the enzyme. Reuter, R., Naumann, M., Bär, J., Miosga, T., Kopperschläger, G. Bioseparation (1998) [Pubmed]
  5. Adenosine diphosphate ribulose in human erythrocytes: a new metabolite with membrane binding properties. Franco, L., Guida, L., Zocchi, E., Silvestro, L., Benatti, U., De Flora, A. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  6. Cloning and characterization of the first two genes of the non-oxidative part of the Saccharomyces cerevisiae pentose-phosphate pathway. Miosga, T., Zimmermann, F.K. Curr. Genet. (1996) [Pubmed]
  7. Pyridoxine biosynthesis in yeast: participation of ribose 5-phosphate ketol-isomerase. Kondo, H., Nakamura, Y., Dong, Y.X., Nikawa, J., Sueda, S. Biochem. J. (2004) [Pubmed]
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