Gene Review:
IXR1 - Ixr1p
Saccharomyces cerevisiae S288c
Synonyms:
Intrastrand cross-link recognition protein, ORD1, SSRP, Structure-specific recognition protein, YKL032C, ...
- A Rox1-independent hypoxic pathway in yeast. Antagonistic action of the repressor Ord1 and activator Yap1 for hypoxic expression of the SRP1/TIR1 gene. Bourdineaud, J.P., De Sampaïo, G., Lauquin, G.J. Mol. Microbiol. (2000)
- Binding of Ixr1, a yeast HMG-domain protein, to cisplatin-DNA adducts in vitro and in vivo. McA'Nulty, M.M., Whitehead, J.P., Lippard, S.J. Biochemistry (1996)
- Ixr1, a yeast protein that binds to platinated DNA and confers sensitivity to cisplatin. Brown, S.J., Kellett, P.J., Lippard, S.J. Science (1993)
- The ORD1 gene encodes a transcription factor involved in oxygen regulation and is identical to IXR1, a gene that confers cisplatin sensitivity to Saccharomyces cerevisiae. Lambert, J.R., Bilanchone, V.W., Cumsky, M.G. Proc. Natl. Acad. Sci. U.S.A. (1994)
- At acidic pH, the GPA2-cAMP pathway is necessary to counteract the ORD1-mediated repression of the hypoxic SRP1/TIR1 yeast gene. Bourdineaud, J.P. Yeast (2001)
- The HMG-domain protein Ixr1 blocks excision repair of cisplatin-DNA adducts in yeast. McA'Nulty, M.M., Lippard, S.J. Mutat. Res. (1996)