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Gene Review

IXR1  -  Ixr1p

Saccharomyces cerevisiae S288c

Synonyms: Intrastrand cross-link recognition protein, ORD1, SSRP, Structure-specific recognition protein, YKL032C, ...
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Disease relevance of IXR1


High impact information on IXR1

  • A yeast strain with an inactivated IXR1 gene was half as sensitive to cisplatin and accumulated one-third as many platinum-DNA lesions after treatment with cisplatin as the parental strain [3].
  • The nucleotide sequence of ORD1 revealed that it is identical to IXR1, a yeast gene whose product contains two high mobility group boxes, binds to platinated DNA, and confers sensitivity to the antitumor drug cisplatin [4].
  • We have found a new hypoxic pathway involving an antagonistic interaction between the Ixr1/Ord1 repressor and the Yap1 factor, a transcriptional activator involved in oxidative stress response [1].
  • The dissociation constant for Ixr1 binding site-specifically to a 92-bp probe containing a single cis-[Pt(NH3)2¿d(GpG)-N7(1) -N7(2)¿] intrastrand cross-link was measured to be 2.5 (+/- 0.1) x 10(-7) M, similar to that found for HMG1 [2].
  • Hydroxyl radical footprinting revealed that Ixr1 protects an area of platinated DNA that is approximately 15 bp in size and centered at the platinum adduct [2].

Biological context of IXR1


Other interactions of IXR1

  • Thus, cAMP allows partial relief of the TIR1 repression exerted by Ord1p [5].
  • The differential sensitivity of wild-type cells and those lacking Ixr1 persisted in the rad1 and rad10 strains, however, indicating that these two proteins act at a stage in the excision repair pathway where damage recognition is less critical [6].


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