The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PKH2  -  Pkh2p

Saccharomyces cerevisiae S288c

Synonyms: HRC1081, PKB-activating kinase homolog 2, Serine/threonine-protein kinase PKH2, YOL100W
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PKH2

  • When overexpressed, a catalytically active C-terminal fragment (kinase domain) of Ypk1 was growth inhibitory; loss of Pkh1 (but not Pkh2) alleviated toxicity [1].

High impact information on PKH2

  • Pkh1p and Pkh2p have an overlapping function because only a mutant with impaired function of both kinases is defective for endocytosis [2].
  • We further demonstrate that Slm proteins are regulated by a phosphorylation/dephosphorylation cycle involving the sphingolipid-activated protein kinases Pkh1 and Pkh2 and the calcium/calmodulin-dependent protein phosphatase calcineurin [3].
  • Using a genetic selection based on a mutant form of the yeast MAP kinase kinase Ste7, we isolated a gene, PKH2, encoding a structurally and functionally conserved yeast homolog of PDK1 [4].
  • The Pkh2 phosphorylation site in Pkc1 (Thr-983) is part of a conserved PDK1 target motif and essential for Pkc1 function [4].
  • Saccharomyces cerevisiae Pkh1 and Pkh2 are functionally redundant homologs of mammalian protein kinase, phosphoinositide-dependent protein kinase-1 [1].

Biological context of PKH2


Associations of PKH2 with chemical compounds

  • We show that overexpression of either one of the two kinases Pkh1p or Pkh2p, that are homologous to mammalian 3-phosphoinositide-dependent kinase-1 (PDK1), can specifically suppress the sphingoid base synthesis requirement for endocytosis [2].


  1. Pkh1 and pkh2 differentially phosphorylate and activate ypk1 and ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Roelants, F.M., Torrance, P.D., Bezman, N., Thorner, J. Mol. Biol. Cell (2002) [Pubmed]
  2. Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. Friant, S., Lombardi, R., Schmelzle, T., Hall, M.N., Riezman, H. EMBO J. (2001) [Pubmed]
  3. The Yeast PH Domain Proteins Slm1 and Slm2 Are Targets of Sphingolipid Signaling during the Response to Heat Stress. Daquinag, A., Fadri, M., Jung, S.Y., Qin, J., Kunz, J. Mol. Cell. Biol. (2007) [Pubmed]
  4. PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Inagaki, M., Schmelzle, T., Yamaguchi, K., Irie, K., Hall, M.N., Matsumoto, K. Mol. Cell. Biol. (1999) [Pubmed]
  5. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Casamayor, A., Torrance, P.D., Kobayashi, T., Thorner, J., Alessi, D.R. Curr. Biol. (1999) [Pubmed]
WikiGenes - Universities