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Gene Review

SCD5  -  Scd5p

Saccharomyces cerevisiae S288c

Synonyms: FTB1, Protein FTB1, Protein SCD5, SCD7, YOR329C
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High impact information on SCD5

  • Finally, we recovered two genes, RED1 and SCD5, with roles in meiosis and the vesicular secretory pathway, respectively [1].
  • Scd5p regulates endocytosis and cortical actin organization as a targeting subunit for the Ser/Thr protein phosphatase-1 (PP1) in yeast [2].
  • We propose that Scd5p can target PP1 to endocytic factors in the cytoplasm that have been disassembled and/or inactivated by phosphorylation [2].
  • Scd5p contains a PP1 binding site, a 3-repeat region of 20 amino acids (3R), and a 9-repeat region of 12 amino acids (9R) [2].
  • We also found that Scd5p undergoes nuclear-cytoplasmic shuttling in a Crm1p-dependent manner [2].

Biological context of SCD5

  • SCD5, an essential gene, encodes a protein important for endocytosis and actin organization in yeast [3].
  • Overexpression of SCD5 partially suppresses the actin defect of clathrin mutants, whereas combining scd5-Delta338 with a clathrin mutation exacerbates the actin and endocytic phenotypes [4].
  • We also showed that Scd5p is required for normal cortical actin organization and endocytosis, possibly as a targeting subunit for protein phosphatase type 1 (PP1) [5].
  • Scd5p contains a central triple repeat (3R) motif related to a known Prk1p consensus phosphorylation site L/IxxQxTG, except that Q is replaced by T [5].
  • Scd5p-DeltaCT lacking the 9R region and its nuclear export signal (NES) accumulates in the nucleus, causing cortical actin and endocytic defects [2].

Physical interactions of SCD5

  • Previous two-hybrid screens showed that Scd5p interacts with Glc7p, a yeast Ser/Thr-specific protein phosphatase-1 (PP1) that participates in a variety of cellular processes [3].

Enzymatic interactions of SCD5

  • In this study we demonstrate that the Scd5p 3R sequence is phosphorylated by Prk1p to negatively regulate Scd5p [5].

Co-localisations of SCD5


Regulatory relationships of SCD5

  • Moreover, at 34 degrees C, overexpression of Scd5p suppresses the temperature sensitivity of a sec2 mutant, which is blocked at a post-Golgi step of the secretory pathway [6].
  • The actin-regulating kinase Prk1p negatively regulates Scd5p, a suppressor of clathrin deficiency, in actin organization and endocytosis [5].

Other interactions of SCD5

  • Although mutation of KVDF had no effect, alteration of KKVRF dramatically reduced Scd5p interaction with Glc7p and resulted in temperature-sensitive growth [3].
  • Furthermore, Sla2p localization at the cell cortex is dependent on Scd5p and clathrin function [4].


  1. Protein phosphatase type 1 interacts with proteins required for meiosis and other cellular processes in Saccharomyces cerevisiae. Tu, J., Song, W., Carlson, M. Mol. Cell. Biol. (1996) [Pubmed]
  2. Cortical recruitment and nuclear-cytoplasmic shuttling of Scd5p, a protein phosphatase-1-targeting protein involved in actin organization and endocytosis. Chang, J.S., Henry, K., Geli, M.I., Lemmon, S.K. Mol. Biol. Cell (2006) [Pubmed]
  3. Protein phosphatase-1 binding to scd5p is important for regulation of actin organization and endocytosis in yeast. Chang, J.S., Henry, K., Wolf, B.L., Geli, M., Lemmon, S.K. J. Biol. Chem. (2002) [Pubmed]
  4. Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast. Henry, K.R., D'Hondt, K., Chang, J., Newpher, T., Huang, K., Hudson, R.T., Riezman, H., Lemmon, S.K. Mol. Biol. Cell (2002) [Pubmed]
  5. The actin-regulating kinase Prk1p negatively regulates Scd5p, a suppressor of clathrin deficiency, in actin organization and endocytosis. Henry, K.R., D'Hondt, K., Chang, J.S., Nix, D.A., Cope, M.J., Chan, C.S., Drubin, D.G., Lemmon, S.K. Curr. Biol. (2003) [Pubmed]
  6. SCD5, a suppressor of clathrin deficiency, encodes a novel protein with a late secretory function in yeast. Nelson, K.K., Holmer, M., Lemmon, S.K. Mol. Biol. Cell (1996) [Pubmed]
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