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Gene Review

IRR1  -  Irr1p

Saccharomyces cerevisiae S288c

Synonyms: Cohesin subunit SCC3, Irregular cell behavior protein 1, SCC3, YIL026C
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High impact information on IRR1

  • Through positional cloning of these genes, we have shown that EVL-14 and SCC-3 are likely the only C. elegans homologs of the yeast sister chromatid cohesion proteins Pds5 and Scc3, respectively [1].
  • These results indicate that EVL-14/PDS-5 and SCC-3 have functions in both mitosis and meiosis [1].
  • The IRR1 protein is localized in the cytosol as verified by immunofluorescence microscopy, and confirmed by cell fractionation and Western blotting [2].
  • Here we show that lowering the level of expression of IRR1 (after fusion with a regulatory catalase A gene promoter) affects colony formation and disturbs zygote formation and spore germination [2].
  • We show that the presence of a mutated copy of IRR1 gene, encoding the F658G substitution in Irr1p, changes the sensitivity of the heterozygous irr1-1/IRR1 diploid to cell wall-affecting compounds [3].

Biological context of IRR1


  1. Caenorhabditis elegans EVL-14/PDS-5 and SCC-3 are essential for sister chromatid cohesion in meiosis and mitosis. Wang, F., Yoder, J., Antoshechkin, I., Han, M. Mol. Cell. Biol. (2003) [Pubmed]
  2. Saccharomyces cerevisiae IRR1 protein is indirectly involved in colony formation. Kurlandzka, A., Rytka, J., Rózalska, B., Wysocka, M. Yeast (1999) [Pubmed]
  3. Substitution F659G in the Irr1p/Scc3p cohesin influences the cell wall of Saccharomyces cerevisiae. Cena, A., Orlowski, J., Machula, K., Fronk, J., Kurlandzka, A. Cell Struct. Funct. (2007) [Pubmed]
  4. Additional copies of the NOG2 and IST2 genes suppress the deficiency of cohesin Irr1p/Scc3p in Saccharomyces cerevisiae. Białkowska, A., Kurlandzka, A. Acta Biochim. Pol. (2002) [Pubmed]
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