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Gene Review

URM1  -  ubiquitin-related modifier URM1

Saccharomyces cerevisiae S288c

Synonyms: Ubiquitin-related modifier 1, YIL008W
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Disease relevance of URM1


High impact information on URM1


Biological context of URM1


Associations of URM1 with chemical compounds

  • Urm1 is conjugated to target proteins, which requires the C-terminal glycine of Urm1 [9].
  • Urm1 and Uba4 show similarity to prokaryotic proteins essential for molybdopterin and thiamin biosynthesis, although the Urm1 system is not involved in these pathways [9].
  • SUMO (small ubiquitin-related modifier) modulates protein structure and function by covalently binding to the lysine side chains of the target proteins [10].

Other interactions of URM1

  • At the first step of this reaction, Urm1 forms a thioester with a novel E1-like protein, Uba4 [9].
  • Simultaneous loss of Urm1p and Cla4p, a p21-activated kinase that functions in budding, is lethal [11].
  • Moreover, treatment of cells with thiol-specific oxidants affects the abundance of Ahp1p-Urm1p conjugates [8].
  • In S phase, even in the absence of exogenous DNA damage, yeast PCNA can be alternatively modified by the small ubiquitin-related modifier protein SUMO; however the consequences of this remain controversial [12].


  1. Non-covalent interaction between nucleocapsid protein of Tula hantavirus and small ubiquitin-related modifier-1, SUMO-1. Kaukinen, P., Vaheri, A., Plyusnin, A. Virus Res. (2003) [Pubmed]
  2. SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae. Cheng, C.H., Lo, Y.H., Liang, S.S., Ti, S.C., Lin, F.M., Yeh, C.H., Huang, H.Y., Wang, T.F. Genes Dev. (2006) [Pubmed]
  3. Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins. Panse, V.G., Küster, B., Gerstberger, T., Hurt, E. Nat. Cell Biol. (2003) [Pubmed]
  4. Small ubiquitin-related modifier pathway is a major determinant of doxorubicin cytotoxicity in Saccharomyces cerevisiae. Huang, R.Y., Kowalski, D., Minderman, H., Gandhi, N., Johnson, E.S. Cancer Res. (2007) [Pubmed]
  5. Pheromone-regulated sumoylation of transcription factors that mediate the invasive to mating developmental switch in yeast. Wang, Y., Dohlman, H.G. J. Biol. Chem. (2006) [Pubmed]
  6. Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage. Jacquiau, H.R., van Waardenburg, R.C., Reid, R.J., Woo, M.H., Guo, H., Johnson, E.S., Bjornsti, M.A. J. Biol. Chem. (2005) [Pubmed]
  7. Smt3/SUMO and Ubc9 are required for efficient APC/C-mediated proteolysis in budding yeast. Dieckhoff, P., Bolte, M., Sancak, Y., Braus, G.H., Irniger, S. Mol. Microbiol. (2004) [Pubmed]
  8. Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p. Goehring, A.S., Rivers, D.M., Sprague, G.F. Eukaryotic Cell (2003) [Pubmed]
  9. A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes. Furukawa, K., Mizushima, N., Noda, T., Ohsumi, Y. J. Biol. Chem. (2000) [Pubmed]
  10. SUMO fusions and SUMO-specific protease for efficient expression and purification of proteins. Malakhov, M.P., Mattern, M.R., Malakhova, O.A., Drinker, M., Weeks, S.D., Butt, T.R. J. Struct. Funct. Genomics (2004) [Pubmed]
  11. Urmylation: a ubiquitin-like pathway that functions during invasive growth and budding in yeast. Goehring, A.S., Rivers, D.M., Sprague, G.F. Mol. Biol. Cell (2003) [Pubmed]
  12. SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase. Pfander, B., Moldovan, G.L., Sacher, M., Hoege, C., Jentsch, S. Nature (2005) [Pubmed]
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