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Gene Review

TEC1  -  Tec1p

Saccharomyces cerevisiae S288c

Synonyms: ROC1, Ty transcription activator TEC1, YBR0750, YBR083W
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High impact information on TEC1

  • Notably, mutation of the phosphoacceptor site in Tec1, deletion of FUS3, or deletion of DIA2 results in a loss of signaling specificity such that pheromone pathway signaling erroneously activates filamentation pathway gene expression and invasive growth [1].
  • Developmental specificity was found to require a transcription factor of the TEA/ATTS family, Tec1, which cooperates with Ste12 during filamentous and invasive growth [2].
  • In vitro gel mobility shift experiments show that Cph2 directly binds to the two sterol regulatory element 1-like elements upstream of TEC1 [3].
  • Interestingly, upstream sequences of all known hypha-specific genes are found to contain potential binding sites for Tec1, a regulator of hyphal development [3].
  • When haploid invasive growth is stimulated by high-copy expression of TEC1, by expression of the dominant hypermorphic allele STE11-4 or by deletion of HOG1, Ty1 transposition is concomitantly activated [4].

Biological context of TEC1

  • The sole element in the TEC1 promoter that has thus far been shown to control Tec1 function is the filament response element [5].
  • This finding suggests a possible role for a homologue of Saccharomyces cerevisiae TEC1 during the activation of proteinase gene expression in C. albicans [6].
  • Involvement of SRE element of Ty1 transposon in TEC1-dependent transcriptional activation [7].
  • This report defines the sequences in Ty1 required for TEC1-dependent activation using a TDH3::lacZ reporter gene in which the UAS was replaced by different portions of a Ty1 or Ty2 element [7].
  • Tec1p and Ste12p have been postulated to regulate these developmental processes primarily by cooperative binding to filamentous and invasion-responsive elements (FREs), which are combined enhancer elements that consist of a Tec1p-binding site (TCS) and an Stel2p-binding site (PRE) [8].

Associations of TEC1 with chemical compounds


Enzymatic interactions of TEC1

  • We present evidence that, during mating, Fus3 phosphorylates Tec1 to downregulate this invasive growth-specific transcription factor and its target genes [10].

Regulatory relationships of TEC1

  • In contrast, the Ste12p-dependent FRE control mechanism is sufficiently executed by the N-terminal portion of Tec1p, which contains the TEA/ATTS DNA-binding domain [8].
  • CaTEC1 complements the pseudohyphal and invasive growth defect of haploid and diploid S. cerevisiae tec1/tec1 mutant cells and strongly activates the promoter of FLO11, a gene required for pseudohyphal growth [6].
  • We suggest that Fus3-triggered Tec1 degradation is an important part of the transcriptional induction of mating genes during the pheromone response [11].

Other interactions of TEC1

  • Activation of FLO11 may thus be the primary means by which Ste12p and Tec1p cause invasive growth [12].
  • Signaling pathway-responsive transcription factors such as Ste12, Tec1, and Flo8 are known to mediate filamentation-specific transcription [13].
  • Mutational analysis of TEC1 revealed that TCS control, FLO11 expression, and haploid invasive growth require the C terminus of Tec1p [8].
  • Cross-talk in ste5-E756G cells was due to both increased activation of Kss1 and reduced Fus3-dependent degradation of the filamentation pathway transcription factor Tec1 [14].
  • In addition, the transcriptional regulators encoded by YCR020C, YBR083W, and YPR199C were expressed differently in the two strains [15].


  1. Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast. Bao, M.Z., Schwartz, M.A., Cantin, G.T., Yates, J.R., Madhani, H.D. Cell (2004) [Pubmed]
  2. Combinatorial control required for the specificity of yeast MAPK signaling. Madhani, H.D., Fink, G.R. Science (1997) [Pubmed]
  3. The basic helix-loop-helix transcription factor Cph2 regulates hyphal development in Candida albicans partly via TEC1. Lane, S., Zhou, S., Pan, T., Dai, Q., Liu, H. Mol. Cell. Biol. (2001) [Pubmed]
  4. Fus3 controls Ty1 transpositional dormancy through the invasive growth MAPK pathway. Conte, D., Curcio, M.J. Mol. Microbiol. (2000) [Pubmed]
  5. The mating factor response pathway regulates transcription of TEC1, a gene involved in pseudohyphal differentiation of Saccharomyces cerevisiae. Oehlen, L., Cross, F.R. FEBS Lett. (1998) [Pubmed]
  6. The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicans. Schweizer, A., Rupp, S., Taylor, B.N., Röllinghoff, M., Schröppel, K. Mol. Microbiol. (2000) [Pubmed]
  7. Involvement of SRE element of Ty1 transposon in TEC1-dependent transcriptional activation. Laloux, I., Jacobs, E., Dubois, E. Nucleic Acids Res. (1994) [Pubmed]
  8. Dual role of the Saccharomyces cerevisiae TEA/ATTS family transcription factor Tec1p in regulation of gene expression and cellular development. Köhler, T., Wesche, S., Taheri, N., Braus, G.H., Mösch, H.U. Eukaryotic Cell (2002) [Pubmed]
  9. A role for the Swe1 checkpoint kinase during filamentous growth of Saccharomyces cerevisiae. La Valle, R., Wittenberg, C. Genetics (2001) [Pubmed]
  10. Differential regulation of Tec1 by Fus3 and Kss1 confers signaling specificity in yeast development. Brückner, S., Köhler, T., Braus, G.H., Heise, B., Bolte, M., Mösch, H.U. Curr. Genet. (2004) [Pubmed]
  11. Fus3-triggered Tec1 degradation modulates mating transcriptional output during the pheromone response. Chou, S., Zhao, S., Song, Y., Liu, H., Nie, Q. Mol. Syst. Biol. (2008) [Pubmed]
  12. The cell surface flocculin Flo11 is required for pseudohyphae formation and invasion by Saccharomyces cerevisiae. Lo, W.S., Dranginis, A.M. Mol. Biol. Cell (1998) [Pubmed]
  13. Identification of Translational Regulation Target Genes during Filamentous Growth in Saccharomyces cerevisiae: Regulatory Role of Caf20 and Dhh1. Park, Y.U., Hur, H., Ka, M., Kim, J. Eukaryotic Cell (2006) [Pubmed]
  14. Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5. Schwartz, M.A., Madhani, H.D. Curr. Genet. (2006) [Pubmed]
  15. Molecular analysis of a Saccharomyces cerevisiae mutant with improved ability to utilize xylose shows enhanced expression of proteins involved in transport, initial xylose metabolism, and the pentose phosphate pathway. Wahlbom, C.F., Cordero Otero, R.R., van Zyl, W.H., Hahn-Hägerdal, B., Jönsson, L.J. Appl. Environ. Microbiol. (2003) [Pubmed]
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