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AHP1  -  Ahp1p

Saccharomyces cerevisiae S288c

Synonyms: AHPC1, Cytoplasmic thiol peroxidase 3, L2916, L9354.5, Peroxiredoxin type II, ...
 
 
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Disease relevance of AHP1

 

High impact information on AHP1

 

Chemical compound and disease context of AHP1

  • We report that Ahp1p protects yeast against toxicity induced by copper, cobalt, chromium, arsenite, arsenate, mercury, zinc and diethyl maleate, suggesting that Ahp1p plays an important role in S. cerevisiae in the protection against metals possibly by reducing peroxides generated in cells by these compounds [1].
 

Biological context of AHP1

 

Anatomical context of AHP1

 

Associations of AHP1 with chemical compounds

  • These data suggest that Ahp1p is a yeast orthologue of prokaryotic AhpC and justifies its name of yeast alkyl hydroperoxide reductase [4].
  • A surfactant, sodium N-lauroyl sarcosinate (SLS), enhanced the solubilization of a few proteins including alkyl hydroperoxide reductase 1 (AHP1) in intact cells, accounting for the absence of this protein in the extract from allicin-treated cells [7].
  • Our study suggests that allicin influences the mode of cell surface localization or the related function of AHP1 as a defense against phospholipid peroxidation by the external action of Cu(2+) [7].
  • Allicin-treated cells and SLS-treated cells similarly showed an increased sensitivity to exogenously added tert-butyl hydroperoxide (t-BOOH), an organic peroxide that is detoxified by the action of AHP1 [7].
  • In vitro treatment of Ahp1 by a large excess of tBuOOH leads to an inactive form, with the catalytic cysteine overoxidized into sulfonate, as demonstrated by (13)C NMR [8].
 

Other interactions of AHP1

  • A second gene, AHP1, was cloned as a suppressor of the Mn2+ tolerance of a delta cmp1 delta cmp2 pmr1 mutant [6].
  • Moreover, treatment of cells with thiol-specific oxidants affects the abundance of Ahp1p-Urm1p conjugates [9].
  • We show results suggesting that during the adaptation period preceding the resumption of inhibited exponential growth under herbicide stress, the antioxidant enzyme Ahp1p and the heat shock proteins Hsp12p and Ssb2p (or Ssb1p) are present in higher amounts [10].
  • Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p [9].

References

  1. Alkyl hydroperoxide reductase 1 protects Saccharomyces cerevisiae against metal ion toxicity and glutathione depletion. Nguyên-nhu, N.T., Knoops, B. Toxicol. Lett. (2002) [Pubmed]
  2. Identification in Saccharomyces cerevisiae of a new stable variant of alkyl hydroperoxide reductase 1 (Ahp1) induced by oxidative stress. Prouzet-Mauléon, V., Monribot-Espagne, C., Boucherie, H., Lagniel, G., Lopez, S., Labarre, J., Garin, J., Lauquin, G.J. J. Biol. Chem. (2002) [Pubmed]
  3. Distinct physiological functions of thiol peroxidase isoenzymes in Saccharomyces cerevisiae. Park, S.G., Cha, M.K., Jeong, W., Kim, I.H. J. Biol. Chem. (2000) [Pubmed]
  4. A new antioxidant with alkyl hydroperoxide defense properties in yeast. Lee, J., Spector, D., Godon, C., Labarre, J., Toledano, M.B. J. Biol. Chem. (1999) [Pubmed]
  5. Dihydroxyacetone detoxification in Saccharomyces cerevisiae involves formaldehyde dissimilation. Molin, M., Blomberg, A. Mol. Microbiol. (2006) [Pubmed]
  6. Involvement of thioredoxin peroxidase type II (Ahp1p) of Saccharomyces cerevisiae in Mn2+ homeostasis. Farcasanu, I.C., Hirata, D., Tsuchiya, E., Mizuta, K., Miyakawa, T. Biosci. Biotechnol. Biochem. (1999) [Pubmed]
  7. Synergistic fungicidal activity of Cu(2+) and allicin, an allyl sulfur compound from garlic, and its relation to the role of alkyl hydroperoxide reductase 1 as a cell surface defense in Saccharomyces cerevisiae. Ogita, A., Hirooka, K., Yamamoto, Y., Tsutsui, N., Fujita, K., Taniguchi, M., Tanaka, T. Toxicology (2005) [Pubmed]
  8. Characterization of the yeast peroxiredoxin Ahp1 in its reduced active and overoxidized inactive forms using NMR. Trivelli, X., Krimm, I., Ebel, C., Verdoucq, L., Prouzet-Mauléon, V., Chartier, Y., Tsan, P., Lauquin, G., Meyer, Y., Lancelin, J.M. Biochemistry (2003) [Pubmed]
  9. Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p. Goehring, A.S., Rivers, D.M., Sprague, G.F. Eukaryotic Cell (2003) [Pubmed]
  10. A proteome analysis of the yeast response to the herbicide 2,4-dichlorophenoxyacetic acid. Teixeira, M.C., Santos, P.M., Fernandes, A.R., Sá-Correia, I. Proteomics (2005) [Pubmed]
 
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